Structural analysis of wss1 protein from saccharomyces cerevisiae
文献类型：期刊论文
| 作者 | Yang, Xiaoyun1; Li, Yanhua2; Gao, Zengqiang2; Li, Zongqiang3; Xu, Jianhua2; Wang, Wenjia4; Dong, Yuhui2 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2017-08-15 |
| 卷号 | 7页码:9 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-08834-w |
| 通讯作者 | Wang, wenjia(wangwenjia@ihep.ac.cn) ; Dong, yuhui(dongyh@ihep.ac.cn) |
| 英文摘要 | Wss1 is a dna-protein crosslinks (dpcs) repair protein, which is responsible for degradation of the protein components in dpcs. in this investigation, crystal structure of the protease domain from saccharomyces cerevisiae wss1 (scwss1) was solved and was compared with the known crystal structure of schizosaccharomyces prombe wss1 (spwss1). it is found that the cleft near zinc ion to be the most conserved core region of wss1 and that the electronic surface distributions vary greatly between the two homologs. solution architecture of the full-length scwss1 was further investigated by small-angle x-ray scattering (saxs), which indicated the protein contains a flexible region inside. finally, based on the structural information, a mechanism was proposed about how the enzyme is activated by dna substrates. |
| WOS关键词 | CROSS-LINK REPAIR ; DNA-REPAIR ; SCATTERING ; SYSTEM |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000407570000147 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177026 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Wenjia; Dong, Yuhui |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China 2.Chinese Acad Sci, Beijing Synchrotron Radiat Facil, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100049, Peoples R China 4.Qilu Univ Technol, Sch Sci, Jinan 250353, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaoyun,Li, Yanhua,Gao, Zengqiang,et al. Structural analysis of wss1 protein from saccharomyces cerevisiae[J]. Scientific reports,2017,7:9. |
| APA | Yang, Xiaoyun.,Li, Yanhua.,Gao, Zengqiang.,Li, Zongqiang.,Xu, Jianhua.,...&Dong, Yuhui.(2017).Structural analysis of wss1 protein from saccharomyces cerevisiae.Scientific reports,7,9. |
| MLA | Yang, Xiaoyun,et al."Structural analysis of wss1 protein from saccharomyces cerevisiae".Scientific reports 7(2017):9. |
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来源：高能物理研究所
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