Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging
文献类型：期刊论文
| 作者 | Wang, Yaling1; Xu, Chao1,3; Chang, Yanan1; Zhao, Lina1; Zhang, Kai4; Zhao, Yuliang1; Gao, Fuping1; Gao, Xueyun2 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-08-30 |
| 卷号 | 9期号:34页码:28959-28966 |
| 关键词 | Bsa Biomineralization Ultrasmall superparamagnetic iron oxide T-2-weighted magnetic resonance imaging |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b10030 |
| 通讯作者 | Gao, xueyun(gaoxy@ihep.ac.cn) |
| 英文摘要 | A facile method to synthesize ultrasmall-sized super magnetic iron oxide nanoparticles with good monodispersity and high relaxivity is desired for magnetic resonance imaging (mri) technology. herein, we have developed a one-step method to direct the formation of superparamagnetic iron oxide nanoparticle (ubspio) using albumin under mild conditions. the resulting ubspio possess ultrasmall size (4.78 +/- 0.55 nm) and super high mr relaxivity (444.56 +/- 8.82 mm(-1) s(-1)). after grafted by the luteinizing hormone release hormone peptide (lhrh), the ubspio could targeted and accumulated in the tumor site. finally, the ubspios had good stability and did not induce cytotoxicity in vitro or major organ toxicity in vivo. the ubspios are promising contrast agents for mri. |
| WOS关键词 | MRI CONTRAST AGENTS ; BIOMEDICAL APPLICATIONS ; DRUG-DELIVERY ; CELLS ; TOMOGRAPHY ; RELAXIVITY ; THERAPY ; DESIGN ; NANOPROBES ; LHRH-PE40 |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000409395500090 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177044 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Xueyun |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing, Peoples R China 3.Shandong Agr Univ, Coll Chem & Mat Sci, Tai An, Shandong, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yaling,Xu, Chao,Chang, Yanan,et al. Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging[J]. Acs applied materials & interfaces,2017,9(34):28959-28966. |
| APA | Wang, Yaling.,Xu, Chao.,Chang, Yanan.,Zhao, Lina.,Zhang, Kai.,...&Gao, Xueyun.(2017).Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging.Acs applied materials & interfaces,9(34),28959-28966. |
| MLA | Wang, Yaling,et al."Ultrasmall superparamagnetic iron oxide nanoparticle for t-2-weighted magnetic resonance imaging".Acs applied materials & interfaces 9.34(2017):28959-28966. |
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来源：高能物理研究所
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