Reconfigurable peptide nanotherapeutics at tumor microenvironmental ph
文献类型：期刊论文
| 作者 | Qiao, Zeng-Ying1; Zhao, Wen-Jing1; Gao, Yu-Juan1; Cong, Yong1; Zhao, Lina2; Hu, Zhiyuan1; Wang, Hao1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-09-13 |
| 卷号 | 9期号:36页码:30426-30436 |
| 关键词 | Peptide Reconfiguration Ph-sensitive Mmp Nanotherapeutics |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b09033 |
| 通讯作者 | Wang, hao(wanghao@nanoctr.cn) |
| 英文摘要 | Peptide nanomaterials have recently attracted considerable interest in the biomedical field. however, their poor bioavailability and less powerful therapeutic efficacy hamper their further applications. herein, we discovered reconfigurable and activated nanotherapeutics in the tumor microenvironment. two peptides, that is, a ph-responsive peptide hlah and a matrix metalloprotease-2 (mmp2)-sensitive peptide with a poly(ethylene glycol) (peg) terminal were conjugated onto the hydrophobic poly(beta-thioester)s backbones to gain the copolymer psh. the therapeutic activity of the hlah peptide could be activated in tumors owing to its reconfiguration under microenvironmental ph. the resultant copolymers self-assembled into nanoparticles under physiological condition, with hlah in cores protected by peg shells. the moderate size (similar to 100 nm) and negative potential enabled the stable circulation of psh in the bloodstream. once arrived at the tumor site, the psh nanoparticles were stimulated by overexpressed mmp2 and acidic ph, and subsequently the shedding of the peg shell and protonation of the hlah peptide induced the reassembly of nanoparticles, resulting in the formation of nanoparticles with activated cytotoxic peptides on the surface. in vivo experiments demonstrated that the reorganized nanoassembly contained three merits: (1) effective accumulation in the tumor site, (2) enhanced antitumor capacity, and (3) no obvious toxic effect at the treatment dose. this on-site reorganization strategy provides an avenue for developing high-performance peptide nanomaterials in cancer treatment. |
| WOS关键词 | DRUG-DELIVERY ; ANTICANCER ACTIVITY ; MOLECULAR-DYNAMICS ; SYSTEMIC TOXICITY ; IN-VIVO ; PHYSICOCHEMICAL CHARACTERISTICS ; PHOTODYNAMIC THERAPY ; NANOPARTICLES ; CHARGE ; REVERSAL |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000411043600021 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177068 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Hao |
| 作者单位 | 1.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiao, Zeng-Ying,Zhao, Wen-Jing,Gao, Yu-Juan,et al. Reconfigurable peptide nanotherapeutics at tumor microenvironmental ph[J]. Acs applied materials & interfaces,2017,9(36):30426-30436. |
| APA | Qiao, Zeng-Ying.,Zhao, Wen-Jing.,Gao, Yu-Juan.,Cong, Yong.,Zhao, Lina.,...&Wang, Hao.(2017).Reconfigurable peptide nanotherapeutics at tumor microenvironmental ph.Acs applied materials & interfaces,9(36),30426-30436. |
| MLA | Qiao, Zeng-Ying,et al."Reconfigurable peptide nanotherapeutics at tumor microenvironmental ph".Acs applied materials & interfaces 9.36(2017):30426-30436. |
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来源：高能物理研究所
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