Overcoming resistance to cisplatin by inhibition of glutathione s-transferases (gsts) with ethacraplatin micelles in vitro and in vivo
文献类型：期刊论文
| 作者 | Li, Shuyi1,2; Li, Chan1,2; Jin, Shubin3; Liu, Juan4; Xue, Xiangdong1; Eltahan, Ahmed Shaker1,2; Sun, Jiadong1; Tan, Jingjie1; Dong, Jinchen1; Liang, Xing-Jie1,2 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 144页码:119-129 |
| 关键词 | Cisplatin resistance Glutathione s-transferases (gsts) Ethacraplatin Drug delivery |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2017.08.021 |
| 通讯作者 | Li, chan(lic@nanoctr.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Platinum-based dna-adducting agents are used extensively in the clinic for cancer chemotherapy. however, the anti-tumor efficacy of these drugs is severely limited by cisplatin resistance, and this can lead to the failure of chemotherapy. one of cisplatin resistance mechanisms is associated with over expression of glutathione s-transferases (gsts), which would accelerate the deactivation of cisplatin and decrease its antitumor efficiency. nanoscale micelles encapsulating ethacraplatin, a conjugate of cisplatin and ethacrynic acid (an effective gsts inhibitor), can enhance the accumulation of active cisplatin in cancer cells by inhibiting the activity of gsts and circumventing deactivation of cisplatin. in vitro and in vivo results provide strong evidence that gsts inhibitor-modified cisplatin prodrug combined with nanoparticle encapsulation favor high effective platinum accumulation, significantly enhanced antitumor efficacy against cisplatin-resistant cancer and decreased system toxicity. it is believed that these ethacraplatin-loaded micelles have the ability of overcoming resistance of cancers toward cisplatin and will improve the prospects for chemotherapy of cisplatin-resistant cancers in the near future. (c) 2017 elsevier ltd. all rights reserved. |
| WOS关键词 | BIODEGRADABLE POLYMER ; DRUG-DELIVERY ; CANCER ; THERAPY ; PRODRUG ; NANOPARTICLES ; MITAPLATIN ; CONJUGATE ; COMPLEXES ; EFFICACY |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000411420000011 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177112 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Chan; Liang, Xing-Jie |
| 作者单位 | 1.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Lab Controllable Nanopharmaceut,Ctr Excellence Na, 11,First North Rd, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Municipal Inst Labour Protect, 55 Taoranting Rd, Beijing 100054, Peoples R China 4.Beijing Inst Transfus Med, Tissue Engn Lab, Beijing 1000850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shuyi,Li, Chan,Jin, Shubin,et al. Overcoming resistance to cisplatin by inhibition of glutathione s-transferases (gsts) with ethacraplatin micelles in vitro and in vivo[J]. Biomaterials,2017,144:119-129. |
| APA | Li, Shuyi.,Li, Chan.,Jin, Shubin.,Liu, Juan.,Xue, Xiangdong.,...&Liang, Xing-Jie.(2017).Overcoming resistance to cisplatin by inhibition of glutathione s-transferases (gsts) with ethacraplatin micelles in vitro and in vivo.Biomaterials,144,119-129. |
| MLA | Li, Shuyi,et al."Overcoming resistance to cisplatin by inhibition of glutathione s-transferases (gsts) with ethacraplatin micelles in vitro and in vivo".Biomaterials 144(2017):119-129. |
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