Extracorporeal shock wave rebuilt subchondral bone in vivo and activated wnt5a/ca2+ signaling in vitro
文献类型：期刊论文
| 作者 | Yu, Lai1,2; Liu, Shuitao3,4; Zhao, Zhe4; Xia, Lin2; Zhang, Haochong4; Lou, Jing4; Yang, Jun4; Xing, Gengmei2; Xing, Gengyan4 |
| 刊名 | Biomed research international
 |
| 出版日期 | 2017 |
| 页码 | 10 |
| ISSN号 | 2314-6133 |
| DOI | 10.1155/2017/1404650 |
| 通讯作者 | Xing, gengyan(xgy1350138@163.com) |
| 英文摘要 | Background. this study aimed to identify the optimal extracorporeal shock wave (esw) intensity and to investigate its effect on subchondral bone rebuilt in vivo and wnt5a/ca2+ signaling in vitro using an osteoarthritis (oa) rat model and bone marrow mesenchymal stem cells (bmmscs), respectively. methods. oa rats treated with (oa + eswgroup) or without (oa group) esw (n = 12/group) were compared with healthy controls (control group, n = 12). gait patterns and subchondral trabecular bone changes were measured. western blot and quantitative real-time polymerase chain reaction detected protein expression and gene transcription, respectively. results. the gait disturbances of oa + esw group were significantly improved compared with the oa group at 6th and 8th weeks. the micro-ct analysis indicated that the bmd, bsv/bv, bv/tv, tr. s, and tr. th are significantly different between oa group and oa + esw group. expression ofwnt5a was increased rapidly after esw treatment at 0.6 bar and peaked after 30 min. conclusions. eswwere positive for bone remodeling in joint tibial condyle subchondral bone of oa rat. esw prevented histological changes in oa and prevented gait disturbance associated with oa progression. optimal intensity of esw induced changes in bmmscs via activation of thewnt5a/ca(2+)z signaling pathway. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; RAT MODEL ; ANTIINFLAMMATORY ACTION ; OSTEOARTHRITIS ; DIFFERENTIATION ; THERAPY ; PAIN ; PATHWAY ; PROLIFERATION ; OSTEOBLASTS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| WOS类目 | Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| 出版者 | HINDAWI LTD |
| WOS记录号 | WOS:000412869000001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177121 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Xing, Gengyan |
| 作者单位 | 1.Xiamen Chang Gung Hosp, Xiamen, Fujian, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 3.Fourth Mil Med Univ, Xian, Shaanxi, Peoples R China 4.Gen Hosp Chinese Peoples Army Police Force, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Lai,Liu, Shuitao,Zhao, Zhe,et al. Extracorporeal shock wave rebuilt subchondral bone in vivo and activated wnt5a/ca2+ signaling in vitro[J]. Biomed research international,2017:10. |
| APA | Yu, Lai.,Liu, Shuitao.,Zhao, Zhe.,Xia, Lin.,Zhang, Haochong.,...&Xing, Gengyan.(2017).Extracorporeal shock wave rebuilt subchondral bone in vivo and activated wnt5a/ca2+ signaling in vitro.Biomed research international,10. |
| MLA | Yu, Lai,et al."Extracorporeal shock wave rebuilt subchondral bone in vivo and activated wnt5a/ca2+ signaling in vitro".Biomed research international (2017):10. |
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来源：高能物理研究所
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