Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects
文献类型：期刊论文
| 作者 | Liu, Yi1,2; Li, Heping1; Xie, Jin2; Zhou, Mengxue2,3; Huang, Hui2,3; Lu, Huiru2; Chai, Zhifang2; Chen, Jun2; Hu, Yi2 |
| 刊名 | Biomaterials science
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 5期号:5页码:1022-1031 |
| ISSN号 | 2047-4830 |
| DOI | 10.1039/c6bm00878j |
| 通讯作者 | Li, heping(lihp@csust.edu.cn) ; Chen, jun(chenjun@ihep.ac.cn) ; Hu, yi(huyi@ihep.ac.cn) |
| 英文摘要 | Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. however, the application of phototherapy is often compromised by its low efficiency. herein, we developed a novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rpaa@swcnts) with a photosensitizer, indocyanine green (icg), for phototherapy. the as-prepared nanoparticles exhibited excellent mitochondria targeting due to the synergistic properties of highly positive charges from the polycations on the corona and the high hydrophobicity from the carbon nanotubes in the core. moreover, the high buffer capacity of the polycations facilitated the endosomal escape of nanoparticles via a proton-sponge effect. when irradiated with an 808 nm nir laser, icg/rpaa@swcnts could precisely damage mitochondria with high efficiency and produce reactive oxygen species (ros) and hyperthermia, which further induced the ros burst from damaged mitochondria. the overproduced ros accumulated in mitochondria ultimately resulted in mitochondrial damage and cell death. therefore icg/rpaa@ swcnts may be able to achieve an amplifying phototherapeutic effect. |
| WOS关键词 | WALLED CARBON NANOTUBES ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; DRUG-DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; CO-DELIVERY ; LIGHT ; CHEMOTHERAPY ; PHOTOSENSITIZER |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000400690700012 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177189 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Heping; Chen, Jun; Hu, Yi |
| 作者单位 | 1.Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Key Lab Rd Struct & Mat, Minist Transport, Changsha 410114, Hunan, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yi,Li, Heping,Xie, Jin,et al. Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects[J]. Biomaterials science,2017,5(5):1022-1031. |
| APA | Liu, Yi.,Li, Heping.,Xie, Jin.,Zhou, Mengxue.,Huang, Hui.,...&Hu, Yi.(2017).Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects.Biomaterials science,5(5),1022-1031. |
| MLA | Liu, Yi,et al."Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects".Biomaterials science 5.5(2017):1022-1031. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。