Gd-dots with strong ligand-water interaction for ultrasensitive magnetic resonance renography
文献类型：期刊论文
| 作者 | Zheng, Xiao-Yu1; Zhao, Kai2; Tang, Jinglong3,4; Wang, Xin-Yu1; Li, Lin-Dong1; Chen, Nai-Xiu1; Wang, Yan-Jie1; Shi, Shuo1; Zhang, Xiaodon2; Malaisamy, Sivakumar1 |
| 刊名 | Acs nano
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 11期号:4页码:3642-3650 |
| 关键词 | Magnetic resonance imaging Contrast agents Nanoparticles Ligand effects Rare earths |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.6b07959 |
| 通讯作者 | Sun, ling-dong(sun@pku.edu.cn) ; Wang, xiaoying(cjr.wangxiaoying@vip.163.com) ; Yan, chun-hua(yan@pku.edu.cn) |
| 英文摘要 | Magnetic resonance imaging contrast agents with both significantly enhanced relaxivity and minimal safety risk are of great importance for sensitive clinical diagnosis, but have rarely been reported. herein, we present a simple strategy to improve relaxivity by introducing surface ligands with strong interaction to water molecules. as a proof of concept, nagdf4 nanoparticles (nps) capped by poly(acrylic acid) (paa) show superior relaxivity to those capped by polyethylenimine and polyethylene glycol, which is attributed to the strong hydrogen-bond capacity of paa to water molecules as revealed by theoretical calculation. furthermore, benefiting from paa and ultrasmall particle size, gd-dots, namely paa-capped gdof nps (2.1 +/- 0.2 nm), are developed as a high-performance contrast agent, with a remarkable ionic relaxivity of similar to 75 mm(-1) s(-1) in albumin solution at 0.5 t. these gd-dots also exhibit efficient renal clearance with <3% of injected amount left 12 h post-injection. ultrasensitive mr renography achieved with gd-dots strongly suggests their great potential for practical applications. |
| WOS关键词 | MRI CONTRAST AGENTS ; RAY COMPUTED-TOMOGRAPHY ; T-1 CONTRAST ; OXIDE NANOPARTICLES ; PROTON RELAXATION ; FIELD-STRENGTH ; GADOLINIUM ; DESIGN ; RELAXIVITY ; CLEARANCE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000400233200022 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177217 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Sun, Ling-Dong; Wang, Xiaoying; Yan, Chun-Hua |
| 作者单位 | 1.Peking Univ, Coll Chem & Mol Engn, PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Che, Beijing Natl Lab Mol Sci,State Key Lab Rare Earth, Beijing 100871, Peoples R China 2.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Xiao-Yu,Zhao, Kai,Tang, Jinglong,et al. Gd-dots with strong ligand-water interaction for ultrasensitive magnetic resonance renography[J]. Acs nano,2017,11(4):3642-3650. |
| APA | Zheng, Xiao-Yu.,Zhao, Kai.,Tang, Jinglong.,Wang, Xin-Yu.,Li, Lin-Dong.,...&Yan, Chun-Hua.(2017).Gd-dots with strong ligand-water interaction for ultrasensitive magnetic resonance renography.Acs nano,11(4),3642-3650. |
| MLA | Zheng, Xiao-Yu,et al."Gd-dots with strong ligand-water interaction for ultrasensitive magnetic resonance renography".Acs nano 11.4(2017):3642-3650. |
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