Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells
文献类型：期刊论文
| 作者 | Xie, Jiani1,2,3; Yong, Yuan1,2,3; Dong, Xinghua1,2,3; Du, Jiangfeng1,2,4,5; Guo, Zhao1,2,3; Gong, Linji1,2,3; Zhu, Shuang1,2; Tian, Gan6,7; Yu, Shicang6,7; Gu, Zhanjun1,2,3 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-04-26 |
| 卷号 | 9期号:16页码:14281-14291 |
| ISSN号 | 1944-8244 |
| 关键词 | Curcumin Bamboo charcoal nanoparticles Bioavailability Chemotherapy Photothermal therapy Radioprotection |
| DOI | 10.1021/acsami.7b02622 |
| 通讯作者 | Gu, zhanjun(zjgu@ihep.ac.cn) |
| 英文摘要 | Low water solubility, extensive metabblism, and drug resistance are the,exiting unavoidable disadvantages of the insoluble drug curcumin in biomedical applications. herein, we employed d-alpha-tocopherol polyethylene glycol 1000 succinate (tpgs)-functionaliieti near-infrared (nir)-triggered photothermal mesoporous nanocarriors. with bamboo charcoal nanoparticles (tpgs-bcnps) to load and deliver curcumni for improving its bioavailability. this system could considerably increase the accumulation of curcumin in cancer cells for enhanced curcumin bioavailability via simultaneously promoting the cellular. internalization of the as-synthesized composite (tpgs-bcnps@curcutnin) by the size effect of nps and: considerably triggering controlled curcurnin release from tpgs-bcnps@curcumin by nir stimulation and reducing efflux of curcumin by the p-glycoprotein (p-gp) inhibition of tpgs, so as to enhance the therapeutie effect of curcumin and realize a better chemo-photothermalsynergetic therapy in vitro and in vivo. besides cancer therapy, studies indicated that :curcumin and some carbon materials could be used as radical scavengers that play an important role in the radioprotection of normal cells. hence, we also investigated the free:radical-stavenging ability of the tpgs-bcnps@curcumin composite in vitro to preliminarily evaluate its radioprotection ability for healthy tissues. therefore, our work provides a multifunctional delivery system for curcumin bioavailability enhancement, chemo-photothermal synergetic therapy of cancer, and radioprotection of healthy tissues. |
| WOS关键词 | IN-VITRO ; MULTIDRUG-RESISTANCE ; GOLD NANOPARTICLES ; PLGA NANOPARTICLES ; MESOPOROUS SILICA ; CELLULAR UPTAKE ; DRUG-DELIVERY ; APOPTOSIS ; VIVO ; TUMOR |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000400321800053 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177226 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gu, Zhanjun |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Soochow Univ, Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China 5.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China 6.Third Mil Med Univ, Affiliated Hosp 1, Inst Pathol, Gaotanyan 30, Chongqing 400038, Peoples R China 7.Third Mil Med Univ, Affiliated Hosp 1, Southwest Canc Ctr, Gaotanyan 30, Chongqing 400038, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Jiani,Yong, Yuan,Dong, Xinghua,et al. Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells[J]. Acs applied materials & interfaces,2017,9(16):14281-14291. |
| APA | Xie, Jiani.,Yong, Yuan.,Dong, Xinghua.,Du, Jiangfeng.,Guo, Zhao.,...&Zhao, Yuliang.(2017).Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells.Acs applied materials & interfaces,9(16),14281-14291. |
| MLA | Xie, Jiani,et al."Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells".Acs applied materials & interfaces 9.16(2017):14281-14291. |
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