Iron modulates the activity of monoamine oxidase b in sh-sy5y cells
文献类型：期刊论文
| 作者 | Lu, Huiru1; Chen, Jun1,2; Huang, Hui1,2; Zhou, Mengxue1,2; Zhu, Qing3; Yao, Shao Q.4; Chai, Zhifang1,2; Hu, Yi1,2 |
| 刊名 | Biometals
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 30期号:4页码:599-607 |
| 关键词 | Iron Mao-b Fluorescence probe |
| ISSN号 | 0966-0844 |
| DOI | 10.1007/s10534-017-0030-1 |
| 通讯作者 | Zhu, qing(zhuq@zjut.edu.cn) ; Hu, yi(huyi@ihep.ac.cn) |
| 英文摘要 | Both monoamine oxidase b (mao-b) and iron accumulation are associated with neurologic diseases including parkinson's disease. however, the association of iron with mao-b activity was poorly understood. here we took advantage of highly sensitive and specific fluorescence probes to examine the change in mao-b activity in human dopaminergic neuroblastoma (sh-sy5y) cells upon iron exposure. both ferric and ferrous ions could significantly enhance the activity of mao-b, instead of mao-a, in sh-sy5y cells. in addition, iron-induced increase in mao-b probe fluorescence could be prevented by pargyline and other newly developed mao-b inhibitors, suggesting that it was mao-b activity-dependent. these findings may suggest mao-b is an important sensor in iron-stressed neuronal cells. |
| WOS关键词 | PARKINSONS-DISEASE ; NEURODEGENERATIVE DISEASES ; INHIBITOR DRUGS ; BRAIN ; PROBE ; NEUROTOXICITY ; METAANALYSIS ; ANTIOXIDANT ; DERIVATIVES ; PREVENTION |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000405780200011 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177242 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhu, Qing; Hu, Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, Multidisciplinary Res Div, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Key Lab Bioorgan Synth Zhejiang Prov, Chaowang Rd 18, Hangzhou 310014, Zhejiang, Peoples R China 4.Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore |
| 推荐引用方式 GB/T 7714 | Lu, Huiru,Chen, Jun,Huang, Hui,et al. Iron modulates the activity of monoamine oxidase b in sh-sy5y cells[J]. Biometals,2017,30(4):599-607. |
| APA | Lu, Huiru.,Chen, Jun.,Huang, Hui.,Zhou, Mengxue.,Zhu, Qing.,...&Hu, Yi.(2017).Iron modulates the activity of monoamine oxidase b in sh-sy5y cells.Biometals,30(4),599-607. |
| MLA | Lu, Huiru,et al."Iron modulates the activity of monoamine oxidase b in sh-sy5y cells".Biometals 30.4(2017):599-607. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。