Iron-induced generation of mitochondrial ros depends on ampk activity
文献类型：期刊论文
| 作者 | Huang, Hui1,2; Chen, Jun1,2; Lu, Huiru1; Zhou, Mengxue1,2; Chai, Zhifang1,2; Hu, Yi1,2 |
| 刊名 | Biometals
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 30期号:4页码:623-628 |
| 关键词 | Fe(ii) Ampk Neurotoxicity Mitochondria Ros |
| ISSN号 | 0966-0844 |
| DOI | 10.1007/s10534-017-0023-0 |
| 通讯作者 | Hu, yi(huyi@ihep.ac.cn) |
| 英文摘要 | Deregulated iron homeostasis is generally believed to be implicated in neurodegenerative diseases, including parkinson's disease. nevertheless, it is not fully understood how iron overload can elicit neuronal cell damage. here we examined mitochondrial reactive oxygen species (ros) levels in human dopaminergic neuroblastoma sh-sy5y cells upon iron exposure. a relatively high concentration of iron could significantly increase mitochondrial ros levels in sh-sy5y cells. pharmacological activation of amp-activated protein kinase (ampk) almost completely inhibited the effect of iron on mitochondrial ros. by contrast, ampk inhibition aggravated the neurotoxicity of iron and enhanced the production of mitochondrial ros. collectively, these findings suggested that excess iron may be able to perturb mitochondrial function, and ampk activity is important for the association of iron and mitochondria. |
| WOS关键词 | PARKINSONS-DISEASE ; SH-SY5Y CELLS ; NEUROTOXICITY ; STRESS ; MTOR ; DRUG |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000405780200014 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177245 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Yi |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, Multidisciplinary Res Div, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Hui,Chen, Jun,Lu, Huiru,et al. Iron-induced generation of mitochondrial ros depends on ampk activity[J]. Biometals,2017,30(4):623-628. |
| APA | Huang, Hui,Chen, Jun,Lu, Huiru,Zhou, Mengxue,Chai, Zhifang,&Hu, Yi.(2017).Iron-induced generation of mitochondrial ros depends on ampk activity.Biometals,30(4),623-628. |
| MLA | Huang, Hui,et al."Iron-induced generation of mitochondrial ros depends on ampk activity".Biometals 30.4(2017):623-628. |
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来源：高能物理研究所
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