Diffusion characteristics of the fornix in patients with alzheimer's disease
文献类型：期刊论文
| 作者 | Tang, Shou Xian1; Feng, Qing Liang2; Wang, Gui Hong3; Duan, Shaofeng4; Shan, Bao Ci4; Dai, Jian Ping1 |
| 刊名 | Psychiatry research-neuroimaging
 |
| 出版日期 | 2017-07-30 |
| 卷号 | 265页码:72-76 |
| 关键词 | Fornix Alzheimer's disease Fractional anisotropy Mean diffusion |
| ISSN号 | 0925-4927 |
| DOI | 10.1016/j.pscychresns.2016.09.012 |
| 通讯作者 | Dai, jian ping(18310585304@163.com) |
| 英文摘要 | White matter degradation is a major part of the pathogenesis of alzheimer's disease (ad). the fornix is the predominant outflow tract from the hippocampus, and alterations to its microstructure in patients with ad are still being explored. diffusion tensor imaging (dti) is an in vivo neuroimaging technique that can provide unique information about alterations in tissue microstructure, which can indicate underlying neurobiological process at the microstructural level. in this prospective study, dti was used to assess and analyze the microstructural features of the fornix in subjects with ad (n = 17), mild cognitive impairment (mci; n = 12) and healthy controls (n = 17). dti was performed using explore dti software and the fsl package. within the fornix, patients with ad showed decreased fractional anisotropy values and length of fiber tracts of the fornix relative to healthy controls, but higher mean diffusivity values. mci subjects showed a trend towards elevated mean diffusivity values in the fornix. the data suggest that dti provides supporting information on the microstructural alteration of the fornix in patients with ad, and that these diffusion characteristics of the fornix may be helpful for the clinical diagnosis of ad. |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; EPISODIC MEMORY ; MRI ; CONNECTIVITY ; TRACTOGRAPHY ; PROGRESSION ; DISRUPTION ; INTEGRITY ; PATHWAYS |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| WOS类目 | Clinical Neurology ; Neuroimaging ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000405053200009 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177268 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Dai, Jian Ping |
| 作者单位 | 1.Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Neuroimaging Ctr, 6 Tiantan Xili, Beijing 100050, Peoples R China 2.Linyi Cent Hosp, Dept Radiol, 17 Kangfu Lu, Linyi 276400, Shandong, Peoples R China 3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Ctr Neurodegenerat Dis, 6 Tiantan Xili, Beijing 100050, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Shou Xian,Feng, Qing Liang,Wang, Gui Hong,et al. Diffusion characteristics of the fornix in patients with alzheimer's disease[J]. Psychiatry research-neuroimaging,2017,265:72-76. |
| APA | Tang, Shou Xian,Feng, Qing Liang,Wang, Gui Hong,Duan, Shaofeng,Shan, Bao Ci,&Dai, Jian Ping.(2017).Diffusion characteristics of the fornix in patients with alzheimer's disease.Psychiatry research-neuroimaging,265,72-76. |
| MLA | Tang, Shou Xian,et al."Diffusion characteristics of the fornix in patients with alzheimer's disease".Psychiatry research-neuroimaging 265(2017):72-76. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。