Universal coating from electrostatic self-assembly to prevent multidrug-resistant bacterial colonization on medical devices and solid surfaces
文献类型：期刊论文
| 作者 | Zheng, Wenshu1,2,3; Jia, Yuexiao1,2; Chen, Wenwen1,2,4; Wang, Guanlin1,2; Guo, Xuefeng3; Jiang, Xingyu1,2 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-06-28 |
| 卷号 | 9期号:25页码:21181-21189 |
| 关键词 | Nosocomial infections Gold nanoparticles Self-assembly Biocompatibility Antimicrobial |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b05230 |
| 通讯作者 | Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | We provide a facile and scalable strategy for preparing gold nanoparticles (aunps)- based antibacterial coating on a variety of surfaces through electrostatic self-assembly. aunps conjugated with 4,6-diamino-2-pyrimidiriethiol (dapt, not antibacterial by itself), audapt, can form stable coating on different substrates made from polyethylene (ps), polyvinyl chloride (pvc), polypropylene (pp), polyethylene (pe), polydirnethylsiloxane (pdms), and sio2 in one step. such a coating can efficiently eradicate pathogenic gram-negative bacteria and even multidrug-resistant (mdr) mutants without causing any side-effect such as cytotoxicity, hemolysis, coagulation, and inflammation. we show that immobilized audapt, instead of audapt released from the substrate, is responsible for killing the bacteria and that the antimicrobial components do not enter into the environment to cause secondary contamination to breed drug resistance. advantages for such coating, include applicability on a broad range of surfaces, low cost, stability, high antibacterial efficiency, good biocompatibility, and low risk in antibiotics pollution; these advantages may be particularly helpful in preventing infections that involve medical devices. |
| WOS关键词 | CAPPED GOLD NANOPARTICLES ; SILVER NANOPARTICLES ; CHARGED NANOPARTICLES ; STAPHYLOCOCCUS-AUREUS ; ANTIBACTERIAL AGENTS ; ANTIBIOTICS ; AGGREGATION ; PNEUMONIAE ; MONOLAYERS ; INFECTION |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000404807200015 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177274 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 4.Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasoun, Sch Biomed Engn, Shenzhen 518060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wenshu,Jia, Yuexiao,Chen, Wenwen,et al. Universal coating from electrostatic self-assembly to prevent multidrug-resistant bacterial colonization on medical devices and solid surfaces[J]. Acs applied materials & interfaces,2017,9(25):21181-21189. |
| APA | Zheng, Wenshu,Jia, Yuexiao,Chen, Wenwen,Wang, Guanlin,Guo, Xuefeng,&Jiang, Xingyu.(2017).Universal coating from electrostatic self-assembly to prevent multidrug-resistant bacterial colonization on medical devices and solid surfaces.Acs applied materials & interfaces,9(25),21181-21189. |
| MLA | Zheng, Wenshu,et al."Universal coating from electrostatic self-assembly to prevent multidrug-resistant bacterial colonization on medical devices and solid surfaces".Acs applied materials & interfaces 9.25(2017):21181-21189. |
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