Biosafety study and mechanism comparison on two types of silica with different nanostructures
文献类型：期刊论文
| 作者 | Zhang, Yang1; Chen, Xianhui1; Zhao, Bo1; Wu, Hounan2; Yuan, Lan2; Zhang, Hua1; Dai, Wenbing1; He, Bing1; Xing, Gengmei3; Zhang, Qiang1,4 |
| 刊名 | Toxicology research
 |
| 出版日期 | 2017-07-01 |
| 卷号 | 6期号:4页码:487-498 |
| ISSN号 | 2045-452X |
| DOI | 10.1039/c7tx00076f |
| 通讯作者 | Wang, xueqing(wangxq@bjmu.edu.cn) |
| 英文摘要 | Silica is frequently used in oral drug delivery; however, its biosafety, particularly concerned with its nanostructure, has not been comprehensively studied yet. here, the in vitro and in vivo biosafety of two types of silica (a200, nano-sized or micron-sized agglomerates; s350, micro-sized particles with nanopores) were compared and the possible reasons for the differences were explored. the results indicated that both a200 and s350 could inhibit the growth of caco-2 cells by inducing apoptosis and changing the cell cycle progression. a200 showed a stronger influence than s350 in most of the in vitro experiments. in the in vivo study in km mice, both a200 and s350 could change the blood constituents under the tested conditions; a200 also increased the levels of inflammatory factors in plasma and the numbers of cd4+ lymphocyte subsets. no obvious organic damage was observed in either the a200-treated or s350-treated groups. the transport study showed that neither a200 nor s350 were readily transported across the intestinal epithelial barrier in vitro and in vivo, but a200 could transport across the lymphaticassociated epithelium and accumulate in the peyer's patches, which might explain the a200-induced immune response. the increased transport of a200 might relate to its particle size, dispersion state and specific surface area. in conclusion, these results demonstrated that a200 and s350 exhibited diverse biosafety aspects, which correlated with their different nanostructures. we believe this study will provide some scientific information about the biosafety of a200 and s350 for their applications in oral drug delivery systems. |
| WOS关键词 | IN-VIVO BIODISTRIBUTION ; OXIDATIVE STRESS ; VITRO TOXICITY ; PARTICLE-SIZE ; NANOPARTICLES ; CELLS ; DELIVERY ; CYTOTOXICITY ; ASSAY ; PHARMACOKINETICS |
| WOS研究方向 | Toxicology |
| WOS类目 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000404873500011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177286 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Xueqing |
| 作者单位 | 1.Peking Univ, Sch Pharmaceut Sci, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100191, Peoples R China 2.Peking Univ, Med & Hlth Analyt Ctr, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 4.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yang,Chen, Xianhui,Zhao, Bo,et al. Biosafety study and mechanism comparison on two types of silica with different nanostructures[J]. Toxicology research,2017,6(4):487-498. |
| APA | Zhang, Yang.,Chen, Xianhui.,Zhao, Bo.,Wu, Hounan.,Yuan, Lan.,...&Wang, Xueqing.(2017).Biosafety study and mechanism comparison on two types of silica with different nanostructures.Toxicology research,6(4),487-498. |
| MLA | Zhang, Yang,et al."Biosafety study and mechanism comparison on two types of silica with different nanostructures".Toxicology research 6.4(2017):487-498. |
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