Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells
文献类型：期刊论文
| 作者 | Fang, Xu1; Wang, Yaling2; Ma, Xiaochuan3; Li, Yingying1; Zhang, Zhaolei1; Xiao, Zhisheng1; Liu, Lijia1; Gao, Xueyun2; Liu, Jian1 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2017-06-14 |
| 卷号 | 5期号:22页码:4190-4197 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c7tb00422b |
| 通讯作者 | Ma, xiaochuan(xcma@suda.edu.cn) ; Liu, jian(jliu@suda.edu.cn) |
| 英文摘要 | Fradiotherapy is an important technology for the clinical treatment of cancer, but the patients suffer from the severe side effects after exposure to radiation. there is an urgent need to develop theranostic agents with excellent imaging capability and effective radiosensitization in order to minimize x-ray irradiation. herein, we report an approach to synthesize peptide-templated au nanoclusters (auncs) for theranostic radiosensitization. a new peptide (ccykfr) is designed for the preparation of auncs with uniform size distribution and fluorescence (656 nm) of high photostability. ccykfr-auncs feature highly efficient targeting/accumulation on mitochondria after endocytosis. with a series of experiments, we demonstrate that ccykfr-auncs irradiated by 4 gy x-rays can introduce a burst of mitoros and severe dna damage leading to cancer cell death. this study presents an important strategy to design theranostic nanomaterials with improved radiosensitization for the development of new anti-cancer therapies. |
| WOS关键词 | GOLD NANOPARTICLES ; X-RAY ; THERAPY ; RADIOTHERAPY ; DNA ; CLUSTERS ; MECHANISMS ; DAMAGE ; ROS ; RADIATION |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000403026400019 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177292 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Ma, Xiaochuan; Liu, Jian |
| 作者单位 | 1.Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Xu,Wang, Yaling,Ma, Xiaochuan,et al. Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells[J]. Journal of materials chemistry b,2017,5(22):4190-4197. |
| APA | Fang, Xu.,Wang, Yaling.,Ma, Xiaochuan.,Li, Yingying.,Zhang, Zhaolei.,...&Liu, Jian.(2017).Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells.Journal of materials chemistry b,5(22),4190-4197. |
| MLA | Fang, Xu,et al."Mitochondria-targeting au nanoclusters enhance radiosensitivity of cancer cells".Journal of materials chemistry b 5.22(2017):4190-4197. |
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来源：高能物理研究所
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