Design of tpgs-functionalized cu3bis3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement
文献类型：期刊论文
| 作者 | Du, Jiangfeng1,2; Zheng, Xiaopeng2; Yong, Yuan2; Yu, Jie2; Dong, Xinghua2,5; Zhang, Chenyang2; Zhou, Ruyi2; Li, Bai2; Yan, Liang2,5; Chen, Chunying3,4 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2017-06-28 |
| 卷号 | 9期号:24页码:8229-8239 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c7nr02213a |
| 通讯作者 | Yan, liang(yanliang@ihep.ac.cn) ; Chen, chunying(chenchy@nanoctr.cn) ; Gu, zhanjun(zjgu@ihep.ac.cn) |
| 英文摘要 | Integrating radiation therapy with high-depth photothermal therapy in the second near-infrared (nir) window is highly required for efficient treatment of deep-seated tumor cells. here, we constructed a multifunctional nano-theranostic with bimetallic chalcogenide nanocrystals (ncs) functionalized with amphiphilic d-alpha-tocopherol polyethylene glycol 1000 succinate (tpgs-cu3bis3). benefiting from the strong absorbance of both x-ray and nir light in the second nir window, tpgs-cu3bis3 cns can not only deposit more radiation dose to trigger enhanced radiation damage in vivo, but also conduct photoinduced hyperthermia for thermal ablation in the second nir window and effective improvement of tumor oxygenation to overcome the hypoxia-associated radio-resistance of tumors. moreover, copper ions on the surface of tpgs-cu3bis3 ncs are capable of catalyzing the fenton-like and haber-weiss reactions to produce highly reactive hydroxyl radicals, leading to the increase in the level of oxygen radicals and further enhance cancer cell destruction. apart from their therapeutic application, by means of x-ray computer tomography imaging as well as multispectral optoacoustic tomography imaging, tpgs-cu3bis3 ncs also have the potential as a nano-theranostic to offer remarkable therapeutic outcome for deep-seated tumor cells in imaging-guided synergistically enhanced radiation therapy. |
| WOS关键词 | GUIDED PHOTOTHERMAL THERAPY ; UP-CONVERSION NANOPARTICLES ; SURFACE-PLASMON RESONANCE ; BISMUTH SULFIDE NANORODS ; IN-VIVO ; SYNERGISTIC THERMORADIOTHERAPY ; GOLD NANOPARTICLES ; CATION-EXCHANGE ; DRUG-DELIVERY ; CANCER |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000403943600022 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177326 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yan, Liang; Chen, Chunying; Gu, Zhanjun |
| 作者单位 | 1.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Jiangfeng,Zheng, Xiaopeng,Yong, Yuan,et al. Design of tpgs-functionalized cu3bis3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement[J]. Nanoscale,2017,9(24):8229-8239. |
| APA | Du, Jiangfeng.,Zheng, Xiaopeng.,Yong, Yuan.,Yu, Jie.,Dong, Xinghua.,...&Zhao, Yuliang.(2017).Design of tpgs-functionalized cu3bis3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement.Nanoscale,9(24),8229-8239. |
| MLA | Du, Jiangfeng,et al."Design of tpgs-functionalized cu3bis3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement".Nanoscale 9.24(2017):8229-8239. |
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