Chiral surface of nanoparticles determines the orientation of adsorbed transferrin and its interaction with receptors
文献类型：期刊论文
| 作者 | Wang, Xinyi1,2,3,4; Wang, Mingzhe1,2,3; Lei, Rong5; Zhu, Shui Fang5; Zhao, Yuliang1,2,3; Chen, Chunying1,2,3 |
| 刊名 | Acs nano
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 11期号:5页码:4606-4616 |
| 关键词 | Gold nanoparticles Chirality Protein corona Transferrin Nanobiological effects |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.7b00200 |
| 通讯作者 | Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | When nanoparticles are exposed to a physiological environment, a "protein corona" is formed that greatly determines their biological fate. adsorption of proteins could be influenced by chiral surfaces of nano particles; however, very few quantitative studies are available on the interaction of protein with the chiral surface of nanoparticles, and the underlying mechanism remains largely unresolved. we have developed a strategy to quantitatively analyze the adsorption and conformational features of transferrin on gold nanoparticles that are functionalized with d, l, and racemic penicillamine. we used a quartz microbalance platform to monitor the interaction of the adsorbed transferrin with transferrin receptors in hek cell-derived liposomes. results show that the chiral surface of nanoparticle determines the orientation and conformation of transferrin, which subsequently affects the interaction and recognition of transferrin with its receptor on the cellular membrane. transferrin is widely used as a tumor-targeting ligand in cancer treatment and diagnosis since the transferrin receptor is overexpressed on the cell membrane of various types of cancer cells. thus, the present results will help to expand the knowledge on biological identity of nanoparticles with chiral surfaces in a physiological environment and provide an insight into the rational design of therapeutic nanoparticles. |
| WOS关键词 | QUANTITATIVE IR SPECTROPHOTOMETRY ; WATER H2O SOLUTIONS ; PROTEIN SECONDARY STRUCTURES ; GOLD NANOPARTICLES ; PEPTIDE COMPOUNDS ; PLASMONIC NANOSTRUCTURES ; ABSORPTION-BANDS ; INFRARED-SPECTRA ; SIZE ; ADSORPTION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000402498400026 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177362 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 4.Shenyang Agr Univ, Coll Sci, Shenyang 110866, Peoples R China 5.Chinese Acad Inspect & Quarantine, Inst Plant Quarantine, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xinyi,Wang, Mingzhe,Lei, Rong,et al. Chiral surface of nanoparticles determines the orientation of adsorbed transferrin and its interaction with receptors[J]. Acs nano,2017,11(5):4606-4616. |
| APA | Wang, Xinyi,Wang, Mingzhe,Lei, Rong,Zhu, Shui Fang,Zhao, Yuliang,&Chen, Chunying.(2017).Chiral surface of nanoparticles determines the orientation of adsorbed transferrin and its interaction with receptors.Acs nano,11(5),4606-4616. |
| MLA | Wang, Xinyi,et al."Chiral surface of nanoparticles determines the orientation of adsorbed transferrin and its interaction with receptors".Acs nano 11.5(2017):4606-4616. |
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