Hybrid prodrug nanoparticles with tumor penetration and programmed drug activation for enhanced chemoresistant cancer therapy
文献类型：期刊论文
| 作者 | Zhao, Caiyan1,2; Shao, Leihou1,2; Lu, Jianqing1; Deng, Xiongwei1; Tong, Yujia1; Wu, Yan1,2 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2017-06-07 |
| 卷号 | 9期号:22页码:18450-18461 |
| ISSN号 | 1944-8244 |
| 关键词 | Nanomedicine Cancer resistance Biological barriers Tumor tissue penetration Programmed activation |
| DOI | 10.1021/acsami.7b01908 |
| 通讯作者 | Wu, yan(wuy@nanoctr.cn) |
| 英文摘要 | Despite nanomedicine having shown great potential for reversing cancer cell resistance, the suboptimal transport across multiple biological obstacles seriously impedes its reaching targets at an efficacious level; which remains a challenging hurdle for clinical success in resistant cancer therapy. here, a lipid-based hybrid nanoparticle was designed to efficiently deliver the therapeutics to resistant cells and treat resistant cancer in vivo. the hybrid nanoparticles (d-nps/tetrandrine (tet)) are composed of a ph-responsive pro drug 1,2-distearoyl-sn-glycero-3-phospho eth an olamin (dspe)doxorubicin (dox), an efflux inhibitor tet, and a surfactant cell dspe-[methoxy (poly(ethylene glycol)) -2000] (dspe-mpeg(2000)); which hierarchically combatted the sequential physiological and pathological barriers of drug resistance and exhibited prolonged blooctcirculation, high tumor accumulation, and deep tumor parenchyma penetration. in the meantime, the programmed stepwise activation of encapsulated tet and dox suppressed the function of resistance-related p-glycoprotein in a timely manner and facilitated the dox sustained accommodation in tumor cells. through systematic studies, the results show that such a nanbsystem dramatically enhances drug potency and significantly overcomes the dox resistance of breast cancer with: negligible systemic toxicities. these findings provide new strategies to systemically combat chemoresistant cancers. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; MULTIDRUG-RESISTANT CANCER ; P-GLYCOPROTEIN ; IN-VIVO ; GOLD NANOPARTICLES ; SHEDDABLE PEG ; DELIVERY ; CELLS ; NANOMEDICINE ; SIZE |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000403136400009 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177363 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wu, Yan |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Caiyan,Shao, Leihou,Lu, Jianqing,et al. Hybrid prodrug nanoparticles with tumor penetration and programmed drug activation for enhanced chemoresistant cancer therapy[J]. Acs applied materials & interfaces,2017,9(22):18450-18461. |
| APA | Zhao, Caiyan,Shao, Leihou,Lu, Jianqing,Deng, Xiongwei,Tong, Yujia,&Wu, Yan.(2017).Hybrid prodrug nanoparticles with tumor penetration and programmed drug activation for enhanced chemoresistant cancer therapy.Acs applied materials & interfaces,9(22),18450-18461. |
| MLA | Zhao, Caiyan,et al."Hybrid prodrug nanoparticles with tumor penetration and programmed drug activation for enhanced chemoresistant cancer therapy".Acs applied materials & interfaces 9.22(2017):18450-18461. |
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来源：高能物理研究所
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