Gold nanoclusters-assisted delivery of ngf sirna for effective treatment of pancreatic cancer
文献类型：期刊论文
| 作者 | Lei, Yifeng1,2,6; Tang, Lixue1,2; Xie, Yangzhouyun1,2; Xianyu, Yunlei1,2; Zhang, Lingmin1,2; Wang, Peng1,2; Hamada, Yoh3; Jiang, Kai4; Zheng, Wenfu1,2; Jiang, Xingyu1,2,5 |
| 刊名 | Nature communications
 |
| 出版日期 | 2017-04-25 |
| 卷号 | 8页码:15 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms15130 |
| 通讯作者 | Zheng, wenfu(zhengwf@nanoctr.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Pancreatic cancer is one of the deadliest human cancers, whose progression is highly dependent on the nervous microenvironment. the suppression of gene expression of nerve growth factor (ngf) may have great potential in pancreatic cancer treatment. here we show that gold nanocluster-assisted delivery of sirna of ngf (gnc-sirna) allows efficient ngf gene silencing and pancreatic cancer treatment. the gnc-sirna complex increases the stability of sirna in serum, prolongs the circulation lifetime of sirna in blood and enhances the cellular uptake and tumour accumulation of sirna. the gnc-sirna complex potently downregulates the ngf expression in panc-1 cells and in pancreatic tumours, and effectively inhibits the tumour progression in three pancreatic tumour models (subcutaneous model, orthotopic model and patient-derived xenograft model) without adverse effects. our study constitutes a straightforward but effective approach to inhibit pancreatic cancer via ngf knockdown, suggesting a promising therapeutic direction for pancreatic cancer. |
| WOS关键词 | NERVE GROWTH-FACTOR ; SPHERICAL NUCLEIC-ACIDS ; DUCTAL ADENOCARCINOMA ; PERINEURAL INVASION ; TUMOR XENOGRAFTS ; MOUSE MODEL ; NANOPARTICLES ; CELLS ; MICE ; THERAPEUTICS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000400110100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177449 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zheng, Wenfu; Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Tohoku Univ, Grad Sch Med, Dept Nanomed Sci, Sendai, Miyagi 9808575, Japan 4.Chinese Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, Beijing 100853, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Wuhan Univ, Cross Disciplinary Inst Engn Sci, Sch Power & Mech Engn, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Yifeng,Tang, Lixue,Xie, Yangzhouyun,et al. Gold nanoclusters-assisted delivery of ngf sirna for effective treatment of pancreatic cancer[J]. Nature communications,2017,8:15. |
| APA | Lei, Yifeng.,Tang, Lixue.,Xie, Yangzhouyun.,Xianyu, Yunlei.,Zhang, Lingmin.,...&Jiang, Xingyu.(2017).Gold nanoclusters-assisted delivery of ngf sirna for effective treatment of pancreatic cancer.Nature communications,8,15. |
| MLA | Lei, Yifeng,et al."Gold nanoclusters-assisted delivery of ngf sirna for effective treatment of pancreatic cancer".Nature communications 8(2017):15. |
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