Triple redox responsive poly(ethylene glycol)-polycaprolactone polymeric nanocarriers for fine-controlled drug release
文献类型：期刊论文
| 作者 | Zhao, Caiyan1,2,3; Shao, Leihou1,2; Lu, Jianqing1,2; Zhao, Chenying1,2; Wei, Yujie1,2,3; Liu, Junxing4; Li, Mingjun4; Wu, Yan1,2 |
| 刊名 | Macromolecular bioscience
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 17期号:4页码:11 |
| 关键词 | Poly(ethylene glycol)-polycaprolactone Stimuliresponsive Drug delivery Triple-disulfide bond |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201600295 |
| 通讯作者 | Li, mingjun(limingjun6116@163.com) ; Wu, yan(wuy@nanoctr.cn) |
| 英文摘要 | Stimuli-responsive nanocarriers with the ability to respond to tumorous heterogeneity have been extensively developed for drug delivery. however, the premature release during blood circulation and insufficient intracellular drug release are still a significant issue. herein, three disulfide bonds are introduced into the amphiphilic poly(ethylene glycol)-polycaprolactone copolymer blocks to form triple-sensitive cleavable polymeric nanocarrier (tri-pesc nps) to improve its sensitivity to narrow glutathione (gsh) concentration. the tri-pesc nps keep intact during blood circulation due to the limited cleaving of triple-disulfide bonds, whereas the loaded drug is efficiently released at tumor cells with the increased concentration of gsh. in vitro studies of doxorubicin-loaded tri-pesc nps show that the nanocarriers achieve sufficient drug release in cancerous cells and inhibit the tumor cells growth, though they only bring minimum damage to normal cells. therefore, the tri-pesc nps with triple-sensitive cleavable bonds hold great promise to improve the therapeutic index in cancer therapy. |
| WOS关键词 | TARGETED SIRNA DELIVERY ; DISULFIDE BONDS ; CANCER-CELLS ; INTRACELLULAR DELIVERY ; COPOLYMER MICELLES ; BLOCK-COPOLYMER ; NANOPARTICLES ; GLUTATHIONE ; PH ; DOXORUBICIN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000398891200006 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177471 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Mingjun; Wu, Yan |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Univ Chem Technol, Coll Sci, Beijing 100029, Peoples R China 4.Jiamusi Univ, Affiliated Hosp 1, Jiamusi 154003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Caiyan,Shao, Leihou,Lu, Jianqing,et al. Triple redox responsive poly(ethylene glycol)-polycaprolactone polymeric nanocarriers for fine-controlled drug release[J]. Macromolecular bioscience,2017,17(4):11. |
| APA | Zhao, Caiyan.,Shao, Leihou.,Lu, Jianqing.,Zhao, Chenying.,Wei, Yujie.,...&Wu, Yan.(2017).Triple redox responsive poly(ethylene glycol)-polycaprolactone polymeric nanocarriers for fine-controlled drug release.Macromolecular bioscience,17(4),11. |
| MLA | Zhao, Caiyan,et al."Triple redox responsive poly(ethylene glycol)-polycaprolactone polymeric nanocarriers for fine-controlled drug release".Macromolecular bioscience 17.4(2017):11. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。