Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor
文献类型：期刊论文
| 作者 | Guo, Zhao1,2; Zhu, Shuang1; Yong, Yuan1,3; Zhang, Xiao1,2,4; Dong, Xinghua1,2; Du, Jiangfeng1,5; Xie, Jiani1,2; Wang, Qing6; Gu, Zhanjun1,2; Zhao, Yuliang1,2,4 |
| 刊名 | Advanced materials
 |
| 出版日期 | 2017-11-27 |
| 卷号 | 29期号:44页码:12 |
| 关键词 | Bismuth oxyiodide Photodynamic therapy Photothermal therapy Radiotherapy Semiconductors |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201704136 |
| 通讯作者 | Gu, zhanjun(zjgu@ihep.ac.cn) ; Zhao, yuliang(yuliangzhao@ihep.ac.cn) |
| 英文摘要 | Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. here, bioi@bi2s3@bsa (bovine serum albumin) semiconductor heterojunction nanoparticles (shnps) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (ct/pa) bioimaging are reported. on the one hand, shnps possess strong x-ray attenuation capability since they contain high-z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement. on the other hand, as a semiconductor, the as-prepared shnps offer an extra approach for reactive oxygen species generation based on electron-hole pair under the irradiation of x-ray through the photodynamic therapy process. this x-ray excited photodynamic therapy obviously has better penetration depth in bio-tissue. what's more, the shnps also possess well photothermal conversion efficiency for photothermal therapy, because bi2s3 is a thin band semiconductor with strong near-infrared absorption that can cause local overheat. in vivo tumor ablation studies show that synergistic radio/photodynamic/photothermal therapy achieves more significant therapeutic effect than any single treatment. in addition, with the strong x-ray attenuation and high near-infrared absorption, the as-obtained shnps can also be applied as a multimodal contrast agent in ct/pa imaging. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; GOLD NANOPARTICLES ; RADIATION-THERAPY ; CANCER-TREATMENT ; QUANTUM DOTS ; PHOTOTHERMAL THERAPY ; NECK-CANCER ; RADIOTHERAPY ; RADIOSENSITIZATION ; OXYGEN |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000415905200025 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177472 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gu, Zhanjun; Zhao, Yuliang |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 3.Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China 4.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 5.Shanxi Med Univ, Hosp 1, Dept Med Imaging, Taiyuan 030001, Shanxi, Peoples R China 6.Shandong Univ Sci & Technol, Inst Nano Engn, Sch Mat Sci & Engn, Qingdao 266590, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Zhao,Zhu, Shuang,Yong, Yuan,et al. Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor[J]. Advanced materials,2017,29(44):12. |
| APA | Guo, Zhao.,Zhu, Shuang.,Yong, Yuan.,Zhang, Xiao.,Dong, Xinghua.,...&Zhao, Yuliang.(2017).Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor.Advanced materials,29(44),12. |
| MLA | Guo, Zhao,et al."Synthesis of bsa-coated bioi@bi2s3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumor".Advanced materials 29.44(2017):12. |
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