Hyaluronic acid modified mpeg-b-pae block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein
文献类型：期刊论文
| 作者 | Li, Cong1; Chen, Rui2,3; Xu, Mengzhen2; Qiao, Jiyan2; Yan, Liang4; Guo, Xin Dong1 |
| 刊名 | Drug delivery
 |
| 出版日期 | 2018 |
| 卷号 | 25期号:1页码:1258-1265 |
| ISSN号 | 1071-7544 |
| 关键词 | Polymer micelles Genistein Ocular delivery Cornea penetration Neovascularization inhibition |
| DOI | 10.1080/10717544.2018.1474972 |
| 通讯作者 | Chen, rui(chenr@nanoctr.cn) ; Guo, xin dong(xdguo@buct.edu.cn) |
| 英文摘要 | The ophthalmic drug delivery is a challenge in the clinical treatment of ocular diseases. the traditional drug administration usually shows apparent limitations, such as the low bioavailability from the reason of low penetration of the cornea and the short survival time of drug in the eyes. to overcome these shortcomings, we propose an amphiphilic polymer micelle modified with hyaluronic acid (ha) for high efficient ophthalmic delivery of genistein, a widely used hydrophobic drug for treatment of ocular angiogenesis. the mpeg-b-pae copolymer was synthesized by the michael addition reaction, and the final drug carrier mpeg-b-pae-g-ha was obtained by the process of esterification. then, genistein was packaged in this drug carrier, getting the final micelles with size of about 84.5 nm. the cell viability tests showed that the micelles take no obvious cytotoxicity to the human cornea epithelium cells. the functionalities of drug slow release and cornea penetration ability were demonstrated in a series ex vivo experiments. further, the vascular inhibition test illustrated that the micelles could significantly inhibit the angiogenesis of human umbilical vein endothelial cells. these results indicate that the constructed polymer has high feasibility to be used as drug carrier in the treatment of ocular diseases. |
| WOS关键词 | RETINAL NEOVASCULARIZATION ; INTRAVITREAL IMPLANT ; MACULAR DEGENERATION ; VIVO EVALUATION ; EYE DISEASE ; NANOPARTICLES ; ANGIOGENESIS ; RETINOPATHY ; SYSTEM ; DEXAMETHASONE |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | TAYLOR & FRANCIS LTD |
| WOS记录号 | WOS:000433944300001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177487 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Rui; Guo, Xin Dong |
| 作者单位 | 1.Beijing Univ Chem Technol, Coll Mat Sci & Engn, Beijing Lab Biomed Mat, Beijing, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Zool, Mol Toxicol Lab, State Key Lab Integrated Management Pest Insects, Beijing, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Cong,Chen, Rui,Xu, Mengzhen,et al. Hyaluronic acid modified mpeg-b-pae block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein[J]. Drug delivery,2018,25(1):1258-1265. |
| APA | Li, Cong,Chen, Rui,Xu, Mengzhen,Qiao, Jiyan,Yan, Liang,&Guo, Xin Dong.(2018).Hyaluronic acid modified mpeg-b-pae block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein.Drug delivery,25(1),1258-1265. |
| MLA | Li, Cong,et al."Hyaluronic acid modified mpeg-b-pae block copolymer aqueous micelles for efficient ophthalmic drug delivery of hydrophobic genistein".Drug delivery 25.1(2018):1258-1265. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。