Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy
文献类型：期刊论文
| 作者 | Xuan, Mingjun1,2; Shao, Jingxin1,2; Zhao, Jie1; Li, Qi1,3; Dai, Luru2; Li, Junbai1,3 |
| 刊名 | Angewandte chemie-international edition
 |
| 出版日期 | 2018-05-22 |
| 卷号 | 57期号:21页码:6049-6053 |
| 关键词 | Magnetic nanoparticles Mesoporous silica Photodynamic therapy Red blood cell membrane Singlet oxygen |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201712996 |
| 通讯作者 | Li, junbai(jbli@iccas.ac.cn) |
| 英文摘要 | Targeted drug delivery is an emerging technological strategy that enables nanoparticle systems to be responsive for tumor therapy. magnetic mesoporous silica nanoparticles (mmsns) were cloaked with red blood cell membrane (rbc). this integrates long circulation, photosensitizer delivery, and magnetic targeting for cancer therapy. invivo experiments demonstrate that rbc@mmsns can avoid immune clearance and achieve magnetic field (mf)-induced high accumulation in a tumor. when light irradiation is applied, singlet oxygen rapidly generates from hypocrellinb (hb)-loaded rbc@mmsn and leads to the necrosis of tumor tissue. such a rbc-cloaked magnetic nanocarrier effectively integrates immunological adjuvant, photosensitizer delivery, mf-assisted targeting photodynamic therapy, which provides an innovative strategy for cancer therapy. |
| WOS关键词 | DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; ERYTHROCYTE-MEMBRANE ; PHOTOTHERMAL THERAPY ; BIOMIMETIC NANOPARTICLES ; POLYMERIC NANOPARTICLES ; GOLD NANOCAGES ; PLATFORM ; NANOCARRIERS ; VACCINATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000432710100007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177516 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Junbai |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, BNLMS, Inst Chem, Beiyijie 2, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beiyitiao 11, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xuan, Mingjun,Shao, Jingxin,Zhao, Jie,et al. Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy[J]. Angewandte chemie-international edition,2018,57(21):6049-6053. |
| APA | Xuan, Mingjun,Shao, Jingxin,Zhao, Jie,Li, Qi,Dai, Luru,&Li, Junbai.(2018).Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy.Angewandte chemie-international edition,57(21),6049-6053. |
| MLA | Xuan, Mingjun,et al."Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy".Angewandte chemie-international edition 57.21(2018):6049-6053. |
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