Molecular cancer imaging in the second near-infrared window using a renal-excreted nir-ii fluorophore-peptide probe
文献类型：期刊论文
| 作者 | Wang, Weizhi1,2; Ma, Zhuoran2; Zhu, Shoujun2; Wan, Hao2; Yue, Jingying2; Ma, Huilong3; Ma, Rui3; Yang, Qinglai3; Wang, Zihua1,4; Li, Qian4 |
| 刊名 | Advanced materials
 |
| 出版日期 | 2018-05-29 |
| 卷号 | 30期号:22页码:8 |
| 关键词 | Molecular imaging Peptide probe Renal-excretion Second near-infrared window Tumor targeting |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201800106 |
| 通讯作者 | Hu, zhiyuan(huzy@nanoctr.cn) ; Liang, yongye(liangyy@sustc.edu.cn) ; Dai, hongjie(hdai@stanford.edu) |
| 英文摘要 | In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. while targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. recently, in vivo fluorescence imaging in the second near-infrared window (nir-ii, 1000-1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. here, a novel peptide (named cp) conjugated nir-ii fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker cd133. the click chemistry derived peptide-dye (cp-irt dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (t/nt > 8). importantly, the cp-irt probes are rapidly renal excreted (approximate to 87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. further, with nir-ii emitting cp-irt probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. the nir-ii fluorescent, cd133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy. |
| WOS关键词 | CELL MARKER CD133 ; STEM-LIKE CELLS ; TUMOR-CELLS ; IN-VIVO ; 1500 NM ; THERAPY ; EFFICACY ; DELIVERY ; NANOPARTICLES ; MICROARRAY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000434034100025 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177522 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Zhiyuan; Liang, Yongye; Dai, Hongjie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 2.Stanford Univ, Dept Chem, Stanford, CA 94305 USA 3.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China 6.Fujian Med Univ, Sch Basic Med Sci, Ctr Neurosci Res, Fuzhou 350108, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Weizhi,Ma, Zhuoran,Zhu, Shoujun,et al. Molecular cancer imaging in the second near-infrared window using a renal-excreted nir-ii fluorophore-peptide probe[J]. Advanced materials,2018,30(22):8. |
| APA | Wang, Weizhi.,Ma, Zhuoran.,Zhu, Shoujun.,Wan, Hao.,Yue, Jingying.,...&Dai, Hongjie.(2018).Molecular cancer imaging in the second near-infrared window using a renal-excreted nir-ii fluorophore-peptide probe.Advanced materials,30(22),8. |
| MLA | Wang, Weizhi,et al."Molecular cancer imaging in the second near-infrared window using a renal-excreted nir-ii fluorophore-peptide probe".Advanced materials 30.22(2018):8. |
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来源：高能物理研究所
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