Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy
文献类型：期刊论文
| 作者 | Ma, Xiaowei1,2; Yang, Xiaolong3; Wang, Yufei1,2; Liu, Juan4; Jin, Shubin5; Li, Shuyi1,2; Liang, Xing-Jie1,2 |
| 刊名 | Nano research
 |
| 出版日期 | 2018-06-01 |
| 卷号 | 11期号:6页码:3419-3433 |
| ISSN号 | 1998-0124 |
| 关键词 | Gold nanoparticles Embryonic development Fetal resorption Differentiation |
| DOI | 10.1007/s12274-018-1969-0 |
| 通讯作者 | Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Gold nanoparticles (au nps) have been widely utilized in biomedical applications owing to their attractive features and biocompatibility, which greatly increase the risk of humans' being exposed to au nps, including pregnant women. in contrast to mature cells, embryos are more susceptible to outside disruptive stimuli. nonetheless, a possible inhibitory effect of nanomaterials on embryonic development is usually ignored as long as the nps do not have significant cytotoxic effects. according to our results, a minimal "nontoxic" concentration of au nps during early pregnancy can have lethal inhibitory effects on embryos in vivo and in vitro. we conducted important experiments on the influence of au nps on embryonic development and found that au nps can disturb embryonic development in a size- and concentration-dependent manner. au nps of 15 nm in diameter downregulated the expression pattern of distinct germ layer markers both at mrna and protein levels; this action prevented differentiation of all three embryonic germ layers. consequently, fetal resorption was observed. our work reveals the impact of au nps on embryonic development and will provide an important guidance and serve as a reference for biomedical applications of au nps with minimal side effects. |
| WOS关键词 | CDSE QUANTUM DOTS ; IN-VIVO ; PLACENTAL BARRIER ; MICE ; PENETRATION ; CANCER ; DIFFERENTIATION ; IMMUNOASSAY ; SCATTERING ; BEHAVIOR |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| 出版者 | TSINGHUA UNIV PRESS |
| WOS记录号 | WOS:000433048600042 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177558 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liang, Xing-Jie |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, 11 First North Rd, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China 4.Beijing Inst Transfus Med, Tissue Engn Lab, Beijing 100850, Peoples R China 5.Beijing Municipal Inst Labour Protect, 55 Taoranting Rd, Beijing 100054, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiaowei,Yang, Xiaolong,Wang, Yufei,et al. Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy[J]. Nano research,2018,11(6):3419-3433. |
| APA | Ma, Xiaowei.,Yang, Xiaolong.,Wang, Yufei.,Liu, Juan.,Jin, Shubin.,...&Liang, Xing-Jie.(2018).Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy.Nano research,11(6),3419-3433. |
| MLA | Ma, Xiaowei,et al."Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy".Nano research 11.6(2018):3419-3433. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。