Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice
文献类型：期刊论文
| 作者 | You, Linhao1,2; Wang, Jing2,5; Liu, Tianqing3; Zhang, Yinlong2,4; Han, Xuexiang2,5; Wang, Ting; Guo, Shanshan2,5; Dong, Tianyu1; Xu, Junchao2,5; Anderson, Gregory J.3 |
| 刊名 | Acs nano
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 12期号:5页码:4123-4139 |
| ISSN号 | 1936-0851 |
| 关键词 | Blood brain barrier Deferoxamine Parkinson's disease Rabies virus glycoprotein 29 Polymeric nanoparticles |
| DOI | 10.1021/acsnano.7b08172 |
| 通讯作者 | Chang, yan-zhong(frankyzchang@yahoo.com.hk) ; Lou, xin(louxin301@gmail.com) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | Excess iron deposition in the brain often causes oxidative stress-related damage and necrosis of dopaminergic neurons in the substantia nigra and has been reported to be one of the major vulnerability factors in parkinson's disease (pd). iron chelation therapy using deferoxamine (dfo) may inhibit this nigrostriatal degeneration and prevent the progress of pd. however, dfo shows very short half-life in vivo and hardly penetrates the blood brain barrier (bbb). hence, it is of great interest to develop dfo formulations for safe and efficient intracerebral drug delivery. herein, we report a polymeric nanoparticle system modified with brain-targeting peptide rabies virus glycoprotein (rvg) 29 that can intracerebrally deliver dfo. the nanoparticle system penetrates the bbb possibly through specific receptor mediated endocytosis triggered by the rvg29 peptide. administration of these nanoparticles significantly decreased iron content and oxidative stress levels in the substantia nigra and striatum of pd mice and effectively reduced their dopaminergic neuron damage and as reversed their neurobehavioral deficits, without causing any overt adverse effects in the brain or other organs. this dfo-based nanoformulation holds great promise for delivery of dfo into the brain and for realizing iron chelation therapy in pd treatment. |
| WOS关键词 | RAT SUBSTANTIA-NIGRA ; STRIATAL DOPAMINERGIC MARKERS ; SOLID LIPID NANOPARTICLES ; ALPHA-SYNUCLEIN ; TRANSPORT PATHWAYS ; IRON CHELATORS ; DISEASE ; CELL ; PEPTIDE ; SYSTEM |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000433404500007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177560 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chang, Yan-Zhong; Lou, Xin; Nie, Guangjun |
| 作者单位 | 1.Hebei Normal Univ, Lab Mol Iron Metab, Coll Life Sci, Shijiazhuang 050024, Hebei, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.PO Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Brisbane, Qld 4029, Australia 4.Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Peoples Liberat Army Gen Hosp, Dept Radiol, 28 Fuxing Rd, Beijing 100853, Peoples R China 7.Univ Sci & Technol China, Chinese Acad Sci, Key Lab Brain Funct & Dis, Hefei 230026, Anhui, Peoples R China 8.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | You, Linhao,Wang, Jing,Liu, Tianqing,et al. Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice[J]. Acs nano,2018,12(5):4123-4139. |
| APA | You, Linhao.,Wang, Jing.,Liu, Tianqing.,Zhang, Yinlong.,Han, Xuexiang.,...&Nie, Guangjun.(2018).Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice.Acs nano,12(5),4123-4139. |
| MLA | You, Linhao,et al."Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice".Acs nano 12.5(2018):4123-4139. |
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来源：高能物理研究所
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