Bio-distribution and bio-availability of silver and gold in rat tissues with silver/gold nanorod administration
文献类型：期刊论文
| 作者 | Wu, Meiyu1; Chen, Liang2; Li, Ruiru1; Dan, Mo3; Liu, Haining1; Wang, Xinsheng1; Wu, Xiaochun1; Liu, Ying4; Xu, Liming2; Xie, Liming1,5 |
| 刊名 | Rsc advances
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:22页码:12260-12268 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c8ra00044a |
| 通讯作者 | Liu, ying(liuy1@nanoctr.cn) ; Xu, liming(xuliming@nicpbp.org.cn) ; Xie, liming(xielm@nanoctr.cn) |
| 英文摘要 | Along with the increasing applications of nanomaterials in medical fields, to know the systemic distribution of nanomaterials in the body through a precise method is required for the biosafety assessment of nanomaterials. in this study, we firstly have established a reliable inductively coupled plasma mass spectrometry (icp-ms) method for concentration measurement of silver (ag) and gold (au) in biological tissues. then, based on this method, the ag or au distribution in rat blood and almost all of the organs were analyzed after an i.v. or s.c. administration of au@ag nrs. both the time-dependent contents of ag and au in blood and two pharmacokinetic models confirmed the rapid clearance of ag from blood. at 24 h after i.v. injection, there was the highest level of ag in liver, followed by portal nodes, spleen, lung, bone marrow and pancreas. in addition, we also found there were gender-related distributions of ag and au in some organs, especially after s.c. injection. therefore, these more comprehensive and important results would give fundamental information for the biological risk assessment of nanomaterials. |
| WOS关键词 | IN-VIVO ; NANOPARTICLES ; TOXICITY ; NANOSTRUCTURES ; MICE ; BIODISTRIBUTION ; HEALTH |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000431976000041 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177592 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Ying; Xu, Liming; Xie, Liming |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, NCNST NIFDC Joint Lab Measurement & Evaluat Nanom, CAS Key Lab Standardizat & Measurement Nanotechno, 11 Beiyitiao Zhongguancun, Beijing 100190, Peoples R China 2.Natl Inst Food & Drug Control, NCNST NIFDC Joint Lab Measurement & Evaluat Nanom, Inst Med Devices Control, Biol Med Ind Base, 31 Huatuo Rd, Beijing 102629, Peoples R China 3.Natl Inst Food & Drug Control, NCNST NIFDC Joint Lab Measurement & Evaluat Nanom, Natl Ctr Safety Evaluat Drugs, 8 Hongda Mid Rd, Beijing 100176, Peoples R China 4.Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, NCNST NIFDC Joint Lab Measurement & Evaluat Nanom, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Beiyitiao Zhongguancun, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Meiyu,Chen, Liang,Li, Ruiru,et al. Bio-distribution and bio-availability of silver and gold in rat tissues with silver/gold nanorod administration[J]. Rsc advances,2018,8(22):12260-12268. |
| APA | Wu, Meiyu.,Chen, Liang.,Li, Ruiru.,Dan, Mo.,Liu, Haining.,...&Xie, Liming.(2018).Bio-distribution and bio-availability of silver and gold in rat tissues with silver/gold nanorod administration.Rsc advances,8(22),12260-12268. |
| MLA | Wu, Meiyu,et al."Bio-distribution and bio-availability of silver and gold in rat tissues with silver/gold nanorod administration".Rsc advances 8.22(2018):12260-12268. |
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来源：高能物理研究所
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