Synthesis of self-assembled porphyrin nanoparticle photosensitizers
文献类型：期刊论文
| 作者 | Wang, Dong1,2; Niu, Lijuan1,2; Qiao, Zeng-Ying3; Cheng, Dong-Bing3; Wang, Jiefei1,2; Zhong, Yong1,2; Bai, Feng1,2; Wang, Hao3; Fan, Hongyou4,5 |
| 刊名 | Acs nano
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 12期号:4页码:3796-3803 |
| 关键词 | Self-assembly Porphyrin nanoparticles Antibacterial photodynamic therapy Apdt Photosensitizers |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.8b01010 |
| 通讯作者 | Bai, feng(baifengsun@126.com) ; Wang, hao(wanghao@nanoctr.cn) ; Fan, hongyou(hfan@sandia.gov) |
| 英文摘要 | The use of nanoparticles as a potential building block for photosensitizers has recently become a focus of interest in the field of photocatalysis and photodynamic therapy. porphyrins and their derivatives are effective photosensitizers due to extended pi-conjugated electronic structure, high molar absorption from visible to near-infrared spectrum, and high singlet oxygen quantum yields as well as chemical versatility. in this paper, we report a synthesis of self-assembled porphyrin nanoparticle photosensitizers using zinc meso-tetra(4-pyridyl)porphyrin (zntpyp) through a confined noncovalent self-assembly process. scanning electron microscopy reveals formation of monodisperse cubic nanoparticles. uv-vis characterizations reveal that optical absorption of the nanoparticles exhibits a red shift due to noncovalent self-assembly of porphyrins, which not only effectively increase intensity of light absorption but also extend light absorption broadly covering visible light for enhanced photodynamic therapy. electron spin-resonance spectroscopy (esr) studies show the resultant porphyrin nanoparticles release a high yield of singlet oxygen. nitric oxide (no) coordinates to central metal zn ions to form stabilized zntpyp@no nanoparticles. we show that under light irradiation zntpyp@no nanoparticles release highly reactive peroxynitrite molecules that exhibit enhanced antibacterial photodynamic therapy (apdt) activity. the ease of the synthesis of self-assembled porphyrin nanoparticles and light triggered release of highly reactive moieties represent a completely different photosensitizer system for apdt application. |
| WOS关键词 | NITRIC-OXIDE ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; PEROXYNITRITE ; NANOSTRUCTURES ; MECHANISM ; BACTERIA ; TYROSINE ; STRESS ; TIO2 |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000431088200076 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177598 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Bai, Feng; Wang, Hao; Fan, Hongyou |
| 作者单位 | 1.Henan Univ, Minist Educ, Key Lab Special Funct Mat, Kaifeng 475004, Peoples R China 2.Henan Univ, Collaborat Innovat Ctr Nano Funct Mat & Applicat, Kaifeng 475004, Peoples R China 3.Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Univ New Mexico, Dept Chem & Biol Engn, Albuquerque, NM 87106 USA 5.Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA |
| 推荐引用方式 GB/T 7714 | Wang, Dong,Niu, Lijuan,Qiao, Zeng-Ying,et al. Synthesis of self-assembled porphyrin nanoparticle photosensitizers[J]. Acs nano,2018,12(4):3796-3803. |
| APA | Wang, Dong.,Niu, Lijuan.,Qiao, Zeng-Ying.,Cheng, Dong-Bing.,Wang, Jiefei.,...&Fan, Hongyou.(2018).Synthesis of self-assembled porphyrin nanoparticle photosensitizers.Acs nano,12(4),3796-3803. |
| MLA | Wang, Dong,et al."Synthesis of self-assembled porphyrin nanoparticle photosensitizers".Acs nano 12.4(2018):3796-3803. |
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来源：高能物理研究所
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