A strategy for rapid construction of blood vessel-like structures with complex cell alignments
文献类型：期刊论文
| 作者 | Wang, Nuoxin1,2,3; Peng, Yunhu2,3,4; Zheng, Wenfu2,3; Tang, Lixue2,3; Cheng, Shiyu2,3; Yang, Junchuan2,3; Liu, Shaoqin1,2,3; Zhang, Wei2,3; Jiang, Xingyu1,2,3,5 |
| 刊名 | Macromolecular bioscience
 |
| 出版日期 | 2018-05-01 |
| 卷号 | 18期号:5页码:12 |
| 关键词 | Blood vessels Cell alignments Fibrin glue Layer by layer Sheath |
| ISSN号 | 1616-5187 |
| DOI | 10.1002/mabi.201700408 |
| 通讯作者 | Liu, shaoqin(shaoqinliu@hit.edu.cn) ; Zhang, wei(zhangw@nanoctr.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | A method is developed that can rapidly produce blood vessel-like structures by bonding cell-laden electrospinning (es) films layer by layer using fibrin glue within 90 min. this strategy allows control of cell type, cell orientation, and material composition in separate layers. furthermore, es films with thicker fibers (polylactic-co-glycolic acid, fiber diameter: approximate to 3.7 mu m) are used as cell-seeding layers to facilitate the cell in-growth; those with thinner fibers (polylactic acid, fiber diameter: approximate to 1.8 mu m) are used as outer reinforcing layers to improve the mechanical strength and reduce the liquid leakage of the scaffold. cells grow, proliferate, and migrate well in the multilayered structure. this design aims at a new type of blood vessel substitute with flexible control of parameters and implementation of functions. |
| WOS关键词 | ENGINEERED VASCULAR GRAFTS ; ELECTROSPUN TUBULAR SCAFFOLD ; SMOOTH-MUSCLE ; TISSUE CONSTRUCTS ; ALGINATE HYDROGEL ; ALIGNED FIBERS ; CURRENT STATE ; IN-VIVO ; FABRICATION ; DIAMETER |
| WOS研究方向 | Biochemistry & Molecular Biology ; Materials Science ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Materials Science, Biomaterials ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000431504100004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177606 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Shaoqin; Zhang, Wei; Jiang, Xingyu |
| 作者单位 | 1.Harbin Inst Technol, Sch Life Sci & Technol, 2 Yikuang Rd, Harbin 150001, Heilongjiang, Peoples R China 2.Beijing Engn Res Ctr BioNanotechnol, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 4.North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA 5.Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Nuoxin,Peng, Yunhu,Zheng, Wenfu,et al. A strategy for rapid construction of blood vessel-like structures with complex cell alignments[J]. Macromolecular bioscience,2018,18(5):12. |
| APA | Wang, Nuoxin.,Peng, Yunhu.,Zheng, Wenfu.,Tang, Lixue.,Cheng, Shiyu.,...&Jiang, Xingyu.(2018).A strategy for rapid construction of blood vessel-like structures with complex cell alignments.Macromolecular bioscience,18(5),12. |
| MLA | Wang, Nuoxin,et al."A strategy for rapid construction of blood vessel-like structures with complex cell alignments".Macromolecular bioscience 18.5(2018):12. |
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来源：高能物理研究所
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