Tc-99m-labeled dtpa-colchicine dimer with improved tumor uptake
文献类型：期刊论文
| 作者 | Wang, Jianjun1,2; Ma, Junping1; Zhao, Qiuyu1; Yang, Wenjiang2; Xue, Jinquan2; Zhang, Yanhua2; Liu, Yu2 |
| 刊名 | Journal of labelled compounds & radiopharmaceuticals
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 61期号:4页码:395-401 |
| 关键词 | Tc-99m Dtpa-colchicine dimer Label Tumor uptake |
| ISSN号 | 0362-4803 |
| DOI | 10.1002/jlcr.3611 |
| 通讯作者 | Wang, jianjun(wangjj2016@ncepu.edu.cn) |
| 英文摘要 | This work reports the synthesis, radiolabeling, and biological studies of tc-99m-diethylene triamine pentaacetic acid (dtpa)-colchicine dimer in tumor-bearing mice. the novel colchicine dimer was successfully synthesized by conjugation of dtpa to 2 colchicine biomolecules. the ligand could be labeled by tc-99m in high yield to get tc-99m-dtpa-colchicine dimer, which was hydrophilic and stable at room temperature. biodistribution and imaging studies in tumor-bearing mice showed that tc-99m-dtpa-colchicine dimer accumulated in the tumor with improved uptake and retention. the results indicate the need for synthetic modification of the parent colchicine derivative and the tc-99m-chelate with a view to improve the tumor-targeting efficacy and in vivo kinetic profiles. |
| WOS关键词 | PRELIMINARY BIODISTRIBUTION ; IN-VIVO ; RADIOPHARMACEUTICALS ; RESISTANCE ; AGENT ; COMPLEX |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Biochemical Research Methods ; Chemistry, Medicinal ; Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000430669000008 |
| 出版者 | WILEY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177616 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Jianjun |
| 作者单位 | 1.North China Elect Power Univ, Coll Environm Sci & Engn, Beijing 100206, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jianjun,Ma, Junping,Zhao, Qiuyu,et al. Tc-99m-labeled dtpa-colchicine dimer with improved tumor uptake[J]. Journal of labelled compounds & radiopharmaceuticals,2018,61(4):395-401. |
| APA | Wang, Jianjun.,Ma, Junping.,Zhao, Qiuyu.,Yang, Wenjiang.,Xue, Jinquan.,...&Liu, Yu.(2018).Tc-99m-labeled dtpa-colchicine dimer with improved tumor uptake.Journal of labelled compounds & radiopharmaceuticals,61(4),395-401. |
| MLA | Wang, Jianjun,et al."Tc-99m-labeled dtpa-colchicine dimer with improved tumor uptake".Journal of labelled compounds & radiopharmaceuticals 61.4(2018):395-401. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。