中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo

文献类型:期刊论文

作者Li, Mengmeng1,2; Wang, Shiwen1,2; Jiang, Jia3; Sun, Jiashu1,2; Li, Yuzhuo3; Huang, Deyong4; Long, Yun-Ze5,6,7; Zheng, Wenfu1,2; Chen, Shiyi3; Jiang, Xingyu1,2
刊名Nanoscale
出版日期2015
卷号7期号:17页码:8071-8075
ISSN号2040-3364
DOI10.1039/c5nr01439e
通讯作者Sun, jiashu(sunjs@nanoctr.cn)
英文摘要The ligament advanced reinforcement system (lars) has been considered as a promising graft for ligament reconstruction. to improve its biocompatibility and effectiveness on new bone formation, we modified the surface of a polyethylene terephthalate (pet) ligament with nanoscale silica using atom transfer radical polymerization (atrp) and silica polymerization. the modified ligament is tested by both in vitro and in vivo experiments. human osteoblast testing in vitro exhibits an similar to 21% higher value in cell viability for silica-modified grafts compared with original grafts. animal testing in vivo shows that there is new formed bone in the case of a nanoscale silica-coated ligament. these results demonstrate that our approach for nanoscale silica surface modification on lars could be potentially applied for ligament reconstruction.
WOS关键词ARTIFICIAL LIGAMENT ; GRAFT OSSEOINTEGRATION ; ELECTROSPUN FIBERS ; FOLLOW-UP ; CELLS ; RECONSTRUCTION ; EXPRESSION ; MATRIX
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种英语
WOS记录号WOS:000353981700066
出版者ROYAL SOC CHEMISTRY
URI标识http://www.irgrid.ac.cn/handle/1471x/2177629
专题高能物理研究所
通讯作者Sun, Jiashu
作者单位1.Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
3.Huashan Hosp, Dept Sports Med, Shanghai, Peoples R China
4.JiShuiTan Hosp, Beijing 100035, Peoples R China
5.Qingdao Univ, Coll Phys, Qingdao 266071, Peoples R China
6.Qingdao Univ, Key Lab Photon Mat & Technol Univ Shandong, Qingdao 266071, Peoples R China
7.Qingdao Univ, State Key Lab Cultivat Base New Fiber Mat & Moder, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714
Li, Mengmeng,Wang, Shiwen,Jiang, Jia,et al. Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo[J]. Nanoscale,2015,7(17):8071-8075.
APA Li, Mengmeng.,Wang, Shiwen.,Jiang, Jia.,Sun, Jiashu.,Li, Yuzhuo.,...&Jiang, Xingyu.(2015).Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo.Nanoscale,7(17),8071-8075.
MLA Li, Mengmeng,et al."Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo".Nanoscale 7.17(2015):8071-8075.

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来源:高能物理研究所

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