Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo
文献类型：期刊论文
| 作者 | Li, Mengmeng1,2; Wang, Shiwen1,2; Jiang, Jia3; Sun, Jiashu1,2; Li, Yuzhuo3; Huang, Deyong4; Long, Yun-Ze5,6,7; Zheng, Wenfu1,2; Chen, Shiyi3; Jiang, Xingyu1,2 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:17页码:8071-8075 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c5nr01439e |
| 通讯作者 | Sun, jiashu(sunjs@nanoctr.cn) |
| 英文摘要 | The ligament advanced reinforcement system (lars) has been considered as a promising graft for ligament reconstruction. to improve its biocompatibility and effectiveness on new bone formation, we modified the surface of a polyethylene terephthalate (pet) ligament with nanoscale silica using atom transfer radical polymerization (atrp) and silica polymerization. the modified ligament is tested by both in vitro and in vivo experiments. human osteoblast testing in vitro exhibits an similar to 21% higher value in cell viability for silica-modified grafts compared with original grafts. animal testing in vivo shows that there is new formed bone in the case of a nanoscale silica-coated ligament. these results demonstrate that our approach for nanoscale silica surface modification on lars could be potentially applied for ligament reconstruction. |
| WOS关键词 | ARTIFICIAL LIGAMENT ; GRAFT OSSEOINTEGRATION ; ELECTROSPUN FIBERS ; FOLLOW-UP ; CELLS ; RECONSTRUCTION ; EXPRESSION ; MATRIX |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000353981700066 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177629 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Sun, Jiashu |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Huashan Hosp, Dept Sports Med, Shanghai, Peoples R China 4.JiShuiTan Hosp, Beijing 100035, Peoples R China 5.Qingdao Univ, Coll Phys, Qingdao 266071, Peoples R China 6.Qingdao Univ, Key Lab Photon Mat & Technol Univ Shandong, Qingdao 266071, Peoples R China 7.Qingdao Univ, State Key Lab Cultivat Base New Fiber Mat & Moder, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mengmeng,Wang, Shiwen,Jiang, Jia,et al. Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo[J]. Nanoscale,2015,7(17):8071-8075. |
| APA | Li, Mengmeng.,Wang, Shiwen.,Jiang, Jia.,Sun, Jiashu.,Li, Yuzhuo.,...&Jiang, Xingyu.(2015).Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo.Nanoscale,7(17),8071-8075. |
| MLA | Li, Mengmeng,et al."Surface modification of nano-silica on the ligament advanced reinforcement system for accelerated bone formation: primary human osteoblasts testing in vitro and animal testing in vivo".Nanoscale 7.17(2015):8071-8075. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。