Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells
文献类型：期刊论文
| 作者 | Hu, Kelei1,2; Zhou, Huige1; Liu, Ying1; Liu, Zhu1; Liu, Jing1; Tang, Jinglong1; Li, Jiayang1; Zhang, Jiakun1; Sheng, Wang2; Zhao, Yuliang1 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:18页码:8607-8618 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c5nr01084e |
| 通讯作者 | Liu, ying(liuy@nanoctr.cn) |
| 英文摘要 | Cancer stem cells (cscs) have the ability to transform into bulk cancer cells, to promote tumor growth and establish tumor metastasis. to effectively inhibit tumor growth and prevent metastasis, treatments with conventional chemotherapy drugs should be combined with csc targeted drugs. in this study, we describe the synthesis and characterization of a new amphiphilic polymer, hyaluronic acid-cystamine-polylactic-co-glycolic acid (ha-ss-plga), composed of a hydrophobic plga head and a hydrophilic ha segment linked by a bioreducible disulfide bond. with a double emulsion method, a nano delivery system was constructed to deliver doxorubicin (dox) and cyclopamine (cyc, a primary inhibitor of the hedgehog signaling pathway of cscs) to both a cd44-overexpressing breast csc subpopulation and bulk breast cancer cells and allow an on-demand release. the resulting drug-loaded nps exhibited a redox-responsive drug release profile. dual drug-loaded particles potently diminished the number and size of tumor-spheres and ha showed a targeting effect towards breast cscs. in vivo combination therapy further demonstrated a remarkable synergistic anti-tumor effect and prolonged survival compared to monotherapy using the orthotopic mammary fat pad tumor growth model. the co-delivery of drug and the csc specific inhibitor towards targeted cancer chemotherapeutics provides an insight into anticancer strategy with facile control and high efficacy. |
| WOS关键词 | HEDGEHOG SIGNALING INHIBITOR ; GOLD NANORODS ; DRUG-DELIVERY ; NANOPARTICLES ; GLUTATHIONE ; METASTASIS ; THERAPY ; RELEASE ; COPOLYMER ; MICELLES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000354044600045 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177630 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China 3.Collaborat Innovat Ctr Radiol Med Jiangsu Higher, Nanjing, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Kelei,Zhou, Huige,Liu, Ying,et al. Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells[J]. Nanoscale,2015,7(18):8607-8618. |
| APA | Hu, Kelei.,Zhou, Huige.,Liu, Ying.,Liu, Zhu.,Liu, Jing.,...&Chen, Chunying.(2015).Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells.Nanoscale,7(18),8607-8618. |
| MLA | Hu, Kelei,et al."Hyaluronic acid functional amphipathic and redox-responsive polymer particles for the co-delivery of doxorubicin and cyclopamine to eradicate breast cancer cells and cancer stem cells".Nanoscale 7.18(2015):8607-8618. |
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来源：高能物理研究所
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