Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells
文献类型：期刊论文
| 作者 | Zhang, Chunqiu1,2; Jin, Shubin1,2; Xue, Xiangdong1,2; Zhang, Tingbin1,2; Jiang, Yonggang1,2; Wang, Paul C.3,4; Liang, Xing-Jie1,2 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2016 |
| 卷号 | 4期号:19页码:3286-3291 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c6tb00612d |
| 通讯作者 | Wang, paul c.(pwang@howard.edu) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | The development of a clinical chemotherapeutic is not an easy task. one challenge is how to deliver the agent to cancer cells. nano-formulation of prodrugs, which combines the strengths of nanotechnology and prodrugs, possesses many advantages for chemotherapeutic drug delivery, including high drug loading efficiency, improved drug availability and enhanced accumulation in cancer cells. here, we have constructed a small library of irinotecan-derived prodrugs, in which the 20-hydroxyl group was derived with fatty-acid moieties through esterification. this conjugation fine-tuned the polarity of the irinotecan molecule, thus enhancing the lipophilicity of the prodrugs and inducing their self-assembly into nanoparticles with different morphologies. these nano-formulated prodrugs accumulated at higher levels in cancer cells and were much more cytotoxic than free drugs. the rational design of prodrug-based nano-formulations opens a new avenue for the engineering of more efficient drug-delivery systems. |
| WOS关键词 | DRUG-DELIVERY ; CONJUGATE NANOPARTICLES ; IN-VITRO ; THERAPY ; NANOTECHNOLOGY ; TUMORS ; VERSATILE ; PLATFORM ; VIVO |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000376039100013 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177776 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Paul C.; Liang, Xing-Jie |
| 作者单位 | 1.Chinese Acad Sci, Ctr Excellence Nanosci, 11 Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China 3.Fu Jen Catholic Univ, Taipei 24205, Taiwan 4.Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Chunqiu,Jin, Shubin,Xue, Xiangdong,et al. Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells[J]. Journal of materials chemistry b,2016,4(19):3286-3291. |
| APA | Zhang, Chunqiu.,Jin, Shubin.,Xue, Xiangdong.,Zhang, Tingbin.,Jiang, Yonggang.,...&Liang, Xing-Jie.(2016).Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells.Journal of materials chemistry b,4(19),3286-3291. |
| MLA | Zhang, Chunqiu,et al."Tunable self-assembly of irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells".Journal of materials chemistry b 4.19(2016):3286-3291. |
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