Mri-guided and ultrasound-triggered release of no by advanced nanomedicine
文献类型：期刊论文
| 作者 | Jin, Zhaokui1; Wen, Yanyuan1; Hu, Yaxin1; Chen, Wenwen1; Zheng, Xianfeng2; Guo, Weisheng3,4; Wang, Tianfu1; Qian, Zhiyong5,6; Su, Bao-Lian2; He, Qianjun1 |
| 刊名 | Nanoscale
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:10页码:3637-3645 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/c7nr00231a |
| 通讯作者 | He, qianjun(nanoflower@126.com) |
| 英文摘要 | Nitric oxide (no) has been well identified as a specific free radical molecule possessing wide-ranging therapeutic effects. targeted delivery and controlled release of no are highly desired to realize precision gas therapy, but are still challenging owing to the non-targetability and uncontrollability of no itself. herein, we propose a new concept of mri-guided and ultrasound-triggered gas release for precision gas therapy. based on this concept, we develop a novel ultrasound-responsive bnn-type no-releasing molecule (norm) and an advanced rattle-type nano-carrier of superparamagnetic iron oxide-encapsulated mesoporous silica nanoparticles (spion@hmsn), and use them to construct a new intelligent nano-medicine (bnn6-spion@hmsn) for the first time. the bnn6-spion@hmsn nanomedicine exhibits excellent passive tumor-targeting capability, high mri-guided tumor localization performance and a unique ultrasound-triggered no release profile. the tumor-targeted, mri-guided and ultrasound-triggered release profiles of the developed nanomedicine enable the tumor site-specific controlled release of no in favor of high-efficacy and safe no gas therapy of tumor. |
| WOS关键词 | NITRIC-OXIDE DELIVERY ; LOADED ECHOGENIC LIPOSOMES ; DRUG-DELIVERY ; NANOPARTICLES ; CANCER ; LIGHT ; MECHANISM ; THERAPY ; TISSUES ; DESIGN |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000397125500035 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177779 |
| 专题 | 高能物理研究所 |
| 通讯作者 | He, Qianjun |
| 作者单位 | 1.Shenzhen Univ, Natl Reg Key Technol Engn Lab Med Ultrasound, Guangdong Key Lab Biomed Measurements & Ultrasoun, Sch Biomed Engn, Shenzhen 518060, Peoples R China 2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Sichuan Univ, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, West China Hosp, Chengdu 610041, Peoples R China 6.Sichuan Univ, Ctr Canc, Collaborat Innovat Ctr Biotherapy, West China Hosp, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Zhaokui,Wen, Yanyuan,Hu, Yaxin,et al. Mri-guided and ultrasound-triggered release of no by advanced nanomedicine[J]. Nanoscale,2017,9(10):3637-3645. |
| APA | Jin, Zhaokui.,Wen, Yanyuan.,Hu, Yaxin.,Chen, Wenwen.,Zheng, Xianfeng.,...&He, Qianjun.(2017).Mri-guided and ultrasound-triggered release of no by advanced nanomedicine.Nanoscale,9(10),3637-3645. |
| MLA | Jin, Zhaokui,et al."Mri-guided and ultrasound-triggered release of no by advanced nanomedicine".Nanoscale 9.10(2017):3637-3645. |
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来源：高能物理研究所
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