Stabilization effect of amino acid side chains in peptide assemblies on graphite studied by scanning tunneling microscopy
文献类型：期刊论文
| 作者 | Guo, Yuanyuan1,2,3; Hou, Jingfei1,2,3; Zhang, Xuemei1,2,3; Yang, Yanlian1,2,3; Wang, Chen1,2,3,4,5 |
| 刊名 | Chemphyschem
 |
| 出版日期 | 2017-04-19 |
| 卷号 | 18期号:8页码:926-934 |
| 关键词 | Aggregation propensity Graphite Peptide assembly Scanning tunneling microscopy Sequence effects |
| ISSN号 | 1439-4235 |
| DOI | 10.1002/cphc.201601353 |
| 通讯作者 | Yang, yanlian(yangyl@nanoctr.cn) ; Wang, chen(wangch@nanoctr.cn) |
| 英文摘要 | An analysis is presented of the effects of amino acid side chains on peptide assemblies in ambient conditions on a graphite surface. the molecularly resolved assemblies of binary peptides are examined with scanning tunneling microscopy. a comparative analysis of the assembly structures reveals that the lamellae width has an appreciable dependence on the peptide sequence, which could be considered as a manifestation of a stabilizing effect of side-chain moieties of amino acids with high (phenylalanine) and low (alanine, asparagine, histidine and aspartic acid) propensities for aggregation. these amino acids are representative for the chemical structures involving the side chains of charged (histidine and aspartic acid), aromatic (phenylalanine), hydrophobic (alanine), and hydrophilic (asparagine) amino acids. these results might provide useful insight for understanding the effects of sequence on the assembly of surface-bound peptides. |
| WOS关键词 | AMYLOID FIBRIL FORMATION ; MOLECULAR-DYNAMICS ; YEAST PRION ; BETA-SHEETS ; SEQUENCE ; PROTEINS ; DETERMINANTS ; AGGREGATION ; NANOTUBES ; CONFORMATION |
| WOS研究方向 | Chemistry ; Physics |
| WOS类目 | Chemistry, Physical ; Physics, Atomic, Molecular & Chemical |
| 语种 | 英语 |
| WOS记录号 | WOS:000402711700009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177782 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yang, Yanlian; Wang, Chen |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Standardizat & Measurement Nanotechno, 11 ZhongGuanCun BeiYiTiao, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yuanyuan,Hou, Jingfei,Zhang, Xuemei,et al. Stabilization effect of amino acid side chains in peptide assemblies on graphite studied by scanning tunneling microscopy[J]. Chemphyschem,2017,18(8):926-934. |
| APA | Guo, Yuanyuan,Hou, Jingfei,Zhang, Xuemei,Yang, Yanlian,&Wang, Chen.(2017).Stabilization effect of amino acid side chains in peptide assemblies on graphite studied by scanning tunneling microscopy.Chemphyschem,18(8),926-934. |
| MLA | Guo, Yuanyuan,et al."Stabilization effect of amino acid side chains in peptide assemblies on graphite studied by scanning tunneling microscopy".Chemphyschem 18.8(2017):926-934. |
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