Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod
文献类型：期刊论文
| 作者 | Zhao, Ruifang1,2,3; Han, Xuexiang1,2,3; Li, Yiye1,3; Wang, Hai1,3; Ji, Tianjiao1,4; Zhao, Yuliang1,3; Nie, Guangjun1,3 |
| 刊名 | Acs nano
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 11期号:8页码:8103-8113 |
| 关键词 | Pancreatic cancer Gold nanoshell Tumor targeting Photothermal effect Chemotherapeutic sensitivity Combination therapy |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.7b02918 |
| 通讯作者 | Li, yiye(liyy@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | Pancreatic cancer, one of the leading causes of cancer-related mortality, is characterized by desmoplasia and hypovascular cancerous tissue, with a 5 year survival rate of <8%. to overcome the severe resistance of pancreatic cancer to conventional therapies, we synthesized gold nanoshell-coated rod-like mesoporous silica (gnrs) nanoparticles which integrated cascade tumor targeting (mediated by photothermal effect and molecular receptor binding) and photothermal treatment enhanced gemcitabine chemotherapy, under mild near-infrared laser irradiation condition. gnrs significantly improved gemcitabine penetration and accumulation in tumor tissues, thus destroying the dense stroma barrier of pancreatic cancer and reinforcing chemosensitivity in mice. our current findings strongly support the notion that further development of this integrated plasmonic photothermal strategy may represent a promising translational nanoformulation for effective treatment of pancreatic cancer with integral cascade tumor targeting strategy and enhanced drug delivery efficacy. |
| WOS关键词 | TRANSFERRIN RECEPTOR ; DRUG-DELIVERY ; POLYMER NANOPARTICLES ; GEMCITABINE ; HYPERTHERMIA ; TUMORS ; CELLS ; SIZE ; TOMOGRAPHY ; STATISTICS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000408520900060 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177783 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Yiye; Nie, Guangjun |
| 作者单位 | 1.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Harvard Med Sch, Childrens Hosp Boston, Div Crit Care Med, Dept Anesthesiol,Lab Biomat & Drug Delivery, 300 Longwood Ave, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Zhao, Ruifang,Han, Xuexiang,Li, Yiye,et al. Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod[J]. Acs nano,2017,11(8):8103-8113. |
| APA | Zhao, Ruifang.,Han, Xuexiang.,Li, Yiye.,Wang, Hai.,Ji, Tianjiao.,...&Nie, Guangjun.(2017).Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod.Acs nano,11(8),8103-8113. |
| MLA | Zhao, Ruifang,et al."Photothermal effect enhanced cascade targeting strategy for improved pancreatic cancer therapy by gold nanoshell@mesoporous silica nanorod".Acs nano 11.8(2017):8103-8113. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。