Determination of protonation constants of o-phospho-l-serine in aqueous solution: potentiometry, microcalorimetry, nmr spectroscopy and quantum chemical calculations
文献类型：期刊论文
| 作者 | Liu, Bijun1; Tian, Yin2; Yu, Qianhong1; Li, Qiang1; Mu, Wanjun1; Tan, Zhaoyi1; Wu, Fengchang3; Wang, Dongqi4; Li, Xingliang1 |
| 刊名 | Journal of solution chemistry
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 46期号:12页码:2281-2292 |
| 关键词 | O-phospho-l-serine Protonation Potentiometry Microcalorimetry Nmr spectroscopy Quantum chemical calculations |
| ISSN号 | 0095-9782 |
| DOI | 10.1007/s10953-017-0696-6 |
| 通讯作者 | Li, xingliang(xingliang@caep.cn) |
| 英文摘要 | O-phospho-l-serine is one of the naturally occurring phosphorylated amino acids, having important pharmacological activity and bioactivity. the protonation constants of o-phospho-l-serine were determined by means of potentiometric titrations at 25 a degrees c and ionic strength of 0.5 mol center dot l-1 (nacl). the heat effects of the protonation reaction of the o-phospho-l-serine were measured by direct calorimetry. nmr spectroscopy has demonstrated that the first protonation site occurs at the nitrogen atom in the amino group, followed by one of the oxygen atoms in the phosphono group, and finally the carboxyl oxygen atom. this trend is in good agreement with the enthalpy of protonation and quantum chemical calculations. these data will help to predict the speciation of o-phospho-l-serine in physiological systems. |
| WOS关键词 | ION BINDING-PROPERTIES ; AMINO-ACIDS ; EQUILIBRIUM-CONSTANTS ; CRYSTAL STRUCTURE ; MOLECULAR STRUCTURES ; METAL-COMPLEXES ; PEPTIDES ; SYSTEMS ; PHOSPHOTHREONINE ; COPPER(II) |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000416160800011 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177792 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Li, Xingliang |
| 作者单位 | 1.China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621999, Sichuan, Peoples R China 2.Southwestern Inst Phys, Chengdu 610041, Sichuan, Peoples R China 3.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China 4.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bijun,Tian, Yin,Yu, Qianhong,et al. Determination of protonation constants of o-phospho-l-serine in aqueous solution: potentiometry, microcalorimetry, nmr spectroscopy and quantum chemical calculations[J]. Journal of solution chemistry,2017,46(12):2281-2292. |
| APA | Liu, Bijun.,Tian, Yin.,Yu, Qianhong.,Li, Qiang.,Mu, Wanjun.,...&Li, Xingliang.(2017).Determination of protonation constants of o-phospho-l-serine in aqueous solution: potentiometry, microcalorimetry, nmr spectroscopy and quantum chemical calculations.Journal of solution chemistry,46(12),2281-2292. |
| MLA | Liu, Bijun,et al."Determination of protonation constants of o-phospho-l-serine in aqueous solution: potentiometry, microcalorimetry, nmr spectroscopy and quantum chemical calculations".Journal of solution chemistry 46.12(2017):2281-2292. |
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