A distinct endocytic mechanism of functionalized-silica nanoparticles in breast cancer stem cells
文献类型：期刊论文
| 作者 | Sun, Jiadong1,2,3; Liu, Yajing1,2; Ge, Min1,2; Zhou, Guoqiang1,2; Sun, Wentong1,2; Liu, Dandan1,2; Liang, Xing-Jie3; Zhang, Jinchao1,2 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2017-11-24 |
| 卷号 | 7页码:13 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-16591-z |
| 通讯作者 | Liu, dandan(leo-liudan@163.com) ; Liang, xing-jie(liangxj@nanoctr.cn) ; Zhang, jinchao(jczhang6970@163.com) |
| 英文摘要 | Nanoparticles provide new fields for life medical science application, including targeted-drug delivery and cancer treatment. to maximize the delivery efficiency of nanoparticle, one must understand the uptake mechanism of nanoparticle in cells, which may determine their ultimate fate and localization in cells. recently, the proposed-cancer stem cell (csc) theory has been attracted great attention and regarded as new targets for the new nanodrug developmet and cancer therapies. the interaction between nanoparticles and cancer cells has been extensively studied, but the uptake mechanism of nanoparticles in cscs has received little attention. here, we use the pharmacological inhibitors of major endocytic pathways to study the silica nanoparticle (sinp) uptake mechanisms in the human breast adenocarcinoma cell line (mcf-7) and mcf-7-derived breast cancer stem cells (bcscs). the results demonstrate that the uptake of sinps, particularly amino-functionalized sinps, in mcf-7 cells is strongly affected by the actin depolymerization, whereas bcscs more strongly inhibit the amino-functionalized sinp uptake after the scavenger receptor disruption. these findings indicate a distinct endocytic mechanism of functionalized sinps in bcscs, which is significant for designing ideal nanosized drug delivery systems and improving the selectivity for csc-targeted therapy. |
| WOS关键词 | CLATHRIN-INDEPENDENT ENDOCYTOSIS ; SURFACE-CHARGE ; ACTIN POLYMERIZATION ; EPITHELIAL-CELLS ; MAMMALIAN-CELLS ; DELIVERY-SYSTEM ; CELLULAR UPTAKE ; DRUG-DELIVERY ; GENE DELIVERY ; INTERNALIZATION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000416135000035 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177796 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Dandan; Liang, Xing-Jie; Zhang, Jinchao |
| 作者单位 | 1.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China 2.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Baoding 071002, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jiadong,Liu, Yajing,Ge, Min,et al. A distinct endocytic mechanism of functionalized-silica nanoparticles in breast cancer stem cells[J]. Scientific reports,2017,7:13. |
| APA | Sun, Jiadong.,Liu, Yajing.,Ge, Min.,Zhou, Guoqiang.,Sun, Wentong.,...&Zhang, Jinchao.(2017).A distinct endocytic mechanism of functionalized-silica nanoparticles in breast cancer stem cells.Scientific reports,7,13. |
| MLA | Sun, Jiadong,et al."A distinct endocytic mechanism of functionalized-silica nanoparticles in breast cancer stem cells".Scientific reports 7(2017):13. |
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来源：高能物理研究所
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