Camptothecin-based nanodrug delivery systems
文献类型：期刊论文
| 作者 | Wen, Yan1,2; Wang, Yingze3; Liu, Xiaoli1; Zhang, Wei1; Xiong, Xinhe4; Han, Zhongxiao5; Liang, Xingjie1,2 |
| 刊名 | Cancer biology & medicine
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 14期号:4页码:363-370 |
| ISSN号 | 2095-3941 |
| 关键词 | Camptothecins Nanomedicine Cancer therapy Drug delivery system |
| DOI | 10.20892/j.issn.2095-3941.2017.0099 |
| 通讯作者 | Liu, xiaoli(liuxiaoli@nanoctr.cn) ; Liang, xingjie(liangxj@nanoctr.cn) |
| 英文摘要 | The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, liver cancer, and lung cancer. camptothecin-based drugs inhibit topoisomerase 1 (topo 1), leading to destruction of dna, and are currently being used as important chemotherapeutic agents in clinical antitumor treatment. however, the main obstacle associated with cancer therapy is represented by systemic toxicity of conventional anticancer drugs and their low accumulation at the tumor site. in addition, low bioavailability, poor water solubility, and other shortcomings hinder their anticancer activity. different from traditional pharmaceutical preparations, nanotechnology-dependent nanopharmaceutical preparations have become one of the main strategies for different countries worldwide to overcome drug development problems. in this review, we summarized the current hotspots and discussed a variety of camptothecin-based nanodrugs for cancer hope that through this review, more efficient drug delivery systems could be designed with potential applications in clinical cancer therapy. |
| WOS关键词 | ADVANCED SOLID TUMORS ; METASTATIC PANCREATIC-CANCER ; PHASE-I ; DRUG-DELIVERY ; INORGANIC NANOPARTICLES ; CARRIER-FREE ; LIPOSOME INJECTION ; DOSE-ESCALATION ; BREAST-CANCER ; THERAPY |
| WOS研究方向 | Oncology ; Research & Experimental Medicine |
| WOS类目 | Oncology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| 出版者 | CHINESE ANTI-CANCER ASSOC |
| WOS记录号 | WOS:000417395500004 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177797 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Xiaoli; Liang, Xingjie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hebei Univ Sci & Technol, Coll Biol Sci & Engn, Shijiazhuang 050018, Hebei, Peoples R China 4.Univ Florida, Herbert Wertheim Coll Engn, Dept Mat Sci & Engn, Gainesville, FL 32611 USA 5.Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Yan,Wang, Yingze,Liu, Xiaoli,et al. Camptothecin-based nanodrug delivery systems[J]. Cancer biology & medicine,2017,14(4):363-370. |
| APA | Wen, Yan.,Wang, Yingze.,Liu, Xiaoli.,Zhang, Wei.,Xiong, Xinhe.,...&Liang, Xingjie.(2017).Camptothecin-based nanodrug delivery systems.Cancer biology & medicine,14(4),363-370. |
| MLA | Wen, Yan,et al."Camptothecin-based nanodrug delivery systems".Cancer biology & medicine 14.4(2017):363-370. |
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来源：高能物理研究所
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