Ige induces hypotension in asthma mice by down-regulating vascular ncx1 expression through activating mir-212-5p
文献类型：期刊论文
| 作者 | Zhao, Hongmei1; Song, Xiaomin1; Yan, Li1; Ren, Meng1; Cui, Xingxing1; Li, Yao1; Gao, Ran1; Zhang, Wei1; Liu, Marobian1; Liu, Bin2 |
| 刊名 | Biochimica et biophysica acta-molecular basis of disease
 |
| 出版日期 | 2018 |
| 卷号 | 1864期号:1页码:189-196 |
| ISSN号 | 0925-4439 |
| 关键词 | Asthma Ige Fc epsilon r1(-/-) Hypotension |
| DOI | 10.1016/j.bbadis.2017.10.011 |
| 通讯作者 | Wang, jing(wangjing@ibms.pumc.edu.cn) |
| 英文摘要 | Immunoglobulin e (ige) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. our current study shows a novel mechanism involving ige, fc epsilon r1, mirna-212-5p (mir-212-5p), and sodium/calcium exchanger protein 1(ncx1) for asthma to induce hypotension. in arterial smooth muscle cells, ige up-regulated mir212-5p via its receptor fcer1, which resulted in down regulation of ncx1 that is a regulating factor for blood pressure. in mice, asthma induced hypotension by interfering vasoconstrictive function; knockout of fcer1 kept the asthmatic mice from developing hypotension; knock-down of mir-212-5p in asthmatic mice resulted in a significant restoration of blood pressure. in human, asthma and ige were positively correlated with hypotension in cohort study on nih epidemiological data. this study suggests a novel therapeutic target (mir-212-5p) for treatment of asthma-induced hypotension. |
| WOS关键词 | SMOOTH-MUSCLE-CELLS ; ANAPHYLACTIC HYPOTENSION ; DIASTOLIC HYPOTENSION ; SUDDEN-DEATH ; HYPERTENSION ; CHILDREN ; RATS ; MANAGEMENT ; RISK |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000418219900018 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177846 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Jing |
| 作者单位 | 1.Chinese Acad Med Sci, State Key Lab Med Mol Biol, Peking Union Med Coll, Dept Pathophysiol,Inst Basic Med Sci,Sch Basic Me, Beijing 100005, Peoples R China 2.Univ Rochester, Dept Biochem & Biophys, 601 Elmwood Ave, Rochester, NY 14642 USA 3.Chinese Acad Sci, Inst High Energy Phys, Multidisciplinary Res Div, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Hongmei,Song, Xiaomin,Yan, Li,et al. Ige induces hypotension in asthma mice by down-regulating vascular ncx1 expression through activating mir-212-5p[J]. Biochimica et biophysica acta-molecular basis of disease,2018,1864(1):189-196. |
| APA | Zhao, Hongmei.,Song, Xiaomin.,Yan, Li.,Ren, Meng.,Cui, Xingxing.,...&Wang, Jing.(2018).Ige induces hypotension in asthma mice by down-regulating vascular ncx1 expression through activating mir-212-5p.Biochimica et biophysica acta-molecular basis of disease,1864(1),189-196. |
| MLA | Zhao, Hongmei,et al."Ige induces hypotension in asthma mice by down-regulating vascular ncx1 expression through activating mir-212-5p".Biochimica et biophysica acta-molecular basis of disease 1864.1(2018):189-196. |
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