Near-infrared guided thermal-responsive nanomedicine against orthotopic superficial bladder cancer
文献类型：期刊论文
| 作者 | Gao, Hui1,2,4; Bi, Ying1,2; Wang, Xin2; Wang, Miao2; Zhou, Mengxue3; Lu, Huiru; Gao, Jimin2; Chen, Jun3; Hu, Yi3 |
| 刊名 | Acs biomaterials science & engineering
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 3期号:12页码:3628-3634 |
| 关键词 | Targeted drug delivery Orthotopic bladder tumor Chemo-photothermal therapy Near-infrared Tumor vasculature |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.7b00405 |
| 通讯作者 | Gao, jimin(jimingao64@163.com) ; Chen, jun(chenjun@ihep.ac.cn) ; Hu, yi(huyi@ihep.ac.cn) |
| 英文摘要 | Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. here we sought to examine the effect of chemo-photothermal therapy on an orthotopic mouse model of superficial bladder cancer. doxorubicin (dox) was encapsulated in cs/pnipaam@swcnts nanoparticles. the biodistribution and antitumor effects of dox-loaded nanoparticles were analyzed. dox-loaded nanoparticles were accumulated in tumor cells upon near-infrared (nir) irradiation and exhibited strong antitumor activity in mice bearing orthotopic bladder tumors. in addition, nir-induced hyperthermia enhanced the permeability of tumor blood vessels, which presumably accounted for specific targeting of the nano medicines to tumors. these results suggest that nir-guided thermal responsive nanomedicines are potentially applicable for chemo-photothermal therapy against orthotopic bladder tumors. |
| WOS关键词 | PHOTOTHERMAL SYNERGISTIC THERAPY ; DRUG-DELIVERY ; ENHANCED PERMEABILITY ; NANOPARTICLES ; DOXORUBICIN ; TUMOR ; NANOCARRIERS ; CHEMOTHERAPY ; HYDROGEL ; PLATFORM |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000418110600057 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177858 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Jimin; Chen, Jun; Hu, Yi |
| 作者单位 | 1.Wenzhou Med Univ, Zhejiang Prov Key Lab Technol & Applicat Model Or, Sch Lab Med & Life Sci, Univ Town, Wenzhou 325035, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 19B Yuquan Rd, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, 19B Yuquan Rd, Beijing 100049, Peoples R China 4.Zhejiang Univ, Sch Med, Childrens Hosp, Clin Lab Dept, 3333 Binsheng Rd, Hangzhou 310052, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Hui,Bi, Ying,Wang, Xin,et al. Near-infrared guided thermal-responsive nanomedicine against orthotopic superficial bladder cancer[J]. Acs biomaterials science & engineering,2017,3(12):3628-3634. |
| APA | Gao, Hui.,Bi, Ying.,Wang, Xin.,Wang, Miao.,Zhou, Mengxue.,...&Hu, Yi.(2017).Near-infrared guided thermal-responsive nanomedicine against orthotopic superficial bladder cancer.Acs biomaterials science & engineering,3(12),3628-3634. |
| MLA | Gao, Hui,et al."Near-infrared guided thermal-responsive nanomedicine against orthotopic superficial bladder cancer".Acs biomaterials science & engineering 3.12(2017):3628-3634. |
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来源：高能物理研究所
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