Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry
文献类型：期刊论文
| 作者 | Zheng, Yuchuan1; Xi, Zhaoyong2; Li, Chan3; Yuan, Siming2; Li, Changjiang1; Liu, Yangzhong2 |
| 刊名 | Inorganic chemistry communications
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 86页码:82-86 |
| 关键词 | Platinum Antitumor Protein Hydrolysis |
| ISSN号 | 1387-7003 |
| DOI | 10.1016/j.inoche.2017.09.030 |
| 通讯作者 | Zheng, yuchuan(zhengyc@hsu.edu.cn) |
| 英文摘要 | Increasing evidence indicates that the copper chaperone atox1 involves the mechanism of pt-drugs. here, the interactions of atox1 with cisplatin and cisplatin analogues were studied. results show that, like cisplatin, the other three pt complexes can interact with atox1 and cu-i coordination obviously enhances the platination of atox1. cisplatin, carboplatin and nedaplatin formed some of adducts with the same composition due to having the same cis-diammine carrier ligands and differ only in the leaving groups. nedaplatin, similar to carboplatin, was relatively inert with respect to cisplatin. remarkably, an unexpected adduct with loss' of the 1, 2-diaminocyclohexane (dach) carrier ligand were observed in the reaction of oxaliplatin with holo-atox1. these results indicate that both platination adducts and rates of platination are significantly influenced by the ligand and cuprous ion, suggesting the probably different influence of atox1 on pt-drugs in vivo. (c) 2017 elsevier b.v. all rights reserved. |
| WOS关键词 | ANTICANCER DRUG CARBOPLATIN ; RESISTANCE ; BINDING ; PROMOTES ; ADDUCTS ; PROTEIN ; CANCER |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000418971600020 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177876 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zheng, Yuchuan |
| 作者单位 | 1.Huangshan Univ, Dept Chem, Huangshan 245041, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, CAS High Magnet Field Lab, Hefei 230026, Anhui, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yuchuan,Xi, Zhaoyong,Li, Chan,et al. Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry[J]. Inorganic chemistry communications,2017,86:82-86. |
| APA | Zheng, Yuchuan,Xi, Zhaoyong,Li, Chan,Yuan, Siming,Li, Changjiang,&Liu, Yangzhong.(2017).Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry.Inorganic chemistry communications,86,82-86. |
| MLA | Zheng, Yuchuan,et al."Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry".Inorganic chemistry communications 86(2017):82-86. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。