Ph switchable nanoassembly for imaging a broad range of malignant tumors
文献类型：期刊论文
| 作者 | Liu, Ye1,2; Qu, Zhuo1,2; Cao, Hongyan1,2; Sun, Hongyan1,2; Gao, Yuan1,2; Jiang, Xingyu1,2,3 |
| 刊名 | Acs nano
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 11期号:12页码:12446-12452 |
| 关键词 | Ph switchable Fluorogenic nanoassembly Bimodal distribution Tumor imaging Biosafety |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.7b06483 |
| 通讯作者 | Gao, yuan(gaoy@nanoctr.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Polymer-based fluorescent nanomaterials have proven to universally image various tumors based on their extremely sharp responsiveness to ph change. such a property has never been realized in supramolecular systems. we herein design a small molecule (dpp-thiophene-4) that is composed of a diketopyrrolopyrrole (dpp) core and two alkyl chains terminated with quaternary ammonium. dpp-thiophene-4 can self-assemble into a nonfluorescent nano assembly when the ph is >7.0 but reversibly disassembles back to fluorescent monomers when the ph is <6.8. meanwhile, its fluorescence emission increases by 10-fold within a 0.2 ph unit change. such a fluorogenic nano assembly can precisely differentiate a number of malignant tumors among normal tissues in vivo due to the slight acidity within tumor microenvironments. further the nanoassembly shows satisfactory biocompatibility and an effective clearance from the body. overall, this supramolecular fluorogenic nanoassembly exhibits an immense potential for realizing broad range tumor diagnosis. |
| WOS关键词 | CANCER INCIDENCE ; HIGHLY FLUORESCENT ; DRUG-DELIVERY ; IN-VIVO ; DIKETOPYRROLOPYRROLE ; AMPLIFICATION ; NANOPARTICLE ; PERFORMANCE ; ASSEMBLIES ; NANOPROBE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000418990200072 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177882 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Yuan; Jiang, Xingyu |
| 作者单位 | 1.Beijing Engn Res Ctr BioNanotechnol, CAS Ctr Excellence Nanosci, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ye,Qu, Zhuo,Cao, Hongyan,et al. Ph switchable nanoassembly for imaging a broad range of malignant tumors[J]. Acs nano,2017,11(12):12446-12452. |
| APA | Liu, Ye,Qu, Zhuo,Cao, Hongyan,Sun, Hongyan,Gao, Yuan,&Jiang, Xingyu.(2017).Ph switchable nanoassembly for imaging a broad range of malignant tumors.Acs nano,11(12),12446-12452. |
| MLA | Liu, Ye,et al."Ph switchable nanoassembly for imaging a broad range of malignant tumors".Acs nano 11.12(2017):12446-12452. |
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来源：高能物理研究所
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