Renal-clearable quaternary chalcogenide nanocrystal for photoacoustic/magnetic resonance imaging guided tumor photothermal therapy
文献类型：期刊论文
| 作者 | Tan, Longfei1; Wan, Jing2; Guo, Weisheng3,4; Ou, Caizhang2; Liu, Tianlong1; Fu, Changhui1; Zhang, Qiang5; Ren, Xiangling1; Liang, Xing-Jie3,4; Ren, Jun1 |
| 刊名 | Biomaterials
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 159页码:108-118 |
| ISSN号 | 0142-9612 |
| 关键词 | Cu2znsns4 Renal-clearable Photothermal therapy Imaging Nanomedicine |
| DOI | 10.1016/j.biomaterials.2018.01.003 |
| 通讯作者 | Zhang, qiang(301zq@live.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) ; Meng, xianwei(mengxw@mail.ipc.ac.cn) |
| 英文摘要 | Ultrasmall cu2znsns4 (czts) nanocrystals with high near infrared (nir) photothermal conversion abilities and peroxidase-mimic properties are synthesized and functionalized with bovine serum albumin (bsa) for rapid clearance multifunctional theranostic platform. due to the presence of cu (i) of czts@bsa, h2o2 could be decomposed to produce highly reactive oxygen species (ros), catalyzed by intrinsic peroxidase like activity of czts. the czts@bsa possesses high nir absorption and excellent photoacoustic (pa) imaging abilities. the as-prepared czts@bsa is also reported as an efficient t1 contrast agent for in vivo mr imaging. therefore, in vivo distribution and rapid renal clearance of czts@bsa are successfully tracked by pa/mr dual-modal-imaging and further proved by icp-ms analysis. systemic acute toxicity evaluation indicates czts@bsa have good biocompatibility to normal tissues and blood. all results reveal that czts@bsa could act as a rapid clearance theranostic nanoplatform for dual-modal-imaging guided tumor ptt. (c) 2018 elsevier ltd. all rights reserved. |
| WOS关键词 | SEMICONDUCTING POLYMER NANOPARTICLES ; CANCER-THERAPY ; THERANOSTIC PLATFORM ; GOLD NANOPARTICLES ; QUANTUM DOTS ; LIVING MICE ; IN-VIVO ; COPPER ; NANOCOMPOSITES ; DEGRADATION |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000425070900010 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177958 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhang, Qiang; Liang, Xing-Jie; Meng, Xianwei |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Controllable Preparat & Applicat Nanomat, State Key Lab Technol Space Cryogen Propellants, 29 East Rd Zhongguancun, Beijing 100190, Peoples R China 2.Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Nanosci, Lab Controllable Nanopharmaceut, Beijing 100190, Peoples R China 4.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Chinese Peoples Liberat Army, Dept Orthopaed, Gen Hosp, Beijing 100853, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Longfei,Wan, Jing,Guo, Weisheng,et al. Renal-clearable quaternary chalcogenide nanocrystal for photoacoustic/magnetic resonance imaging guided tumor photothermal therapy[J]. Biomaterials,2018,159:108-118. |
| APA | Tan, Longfei.,Wan, Jing.,Guo, Weisheng.,Ou, Caizhang.,Liu, Tianlong.,...&Meng, Xianwei.(2018).Renal-clearable quaternary chalcogenide nanocrystal for photoacoustic/magnetic resonance imaging guided tumor photothermal therapy.Biomaterials,159,108-118. |
| MLA | Tan, Longfei,et al."Renal-clearable quaternary chalcogenide nanocrystal for photoacoustic/magnetic resonance imaging guided tumor photothermal therapy".Biomaterials 159(2018):108-118. |
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来源：高能物理研究所
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