Chaperonin-groel as a smart hydrophobic drug delivery and tumor targeting molecular machine for tumor therapy
文献类型：期刊论文
| 作者 | Yuan, Yi1; Du, Chong1,2; Sun, Cuiji1; Zhu, Jin1; Wu, Shan3; Zhang, Yinlong1,4; Ji, Tianjiao1; Lei, Jianlin3; Yang, Yinmo2; Gao, Ning3,5 |
| 刊名 | Nano letters
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 18期号:2页码:921-928 |
| 关键词 | Chaperonin Groel Nanocarrier Atp excitation Hydrophobic drug delivery Tumor targeting |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.7b04307 |
| 通讯作者 | Gao, ning(gaon@pku.edu.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | The targeted delivery of hydrophobic therapeutic drugs to tumors is one of the major challenges in drug development. the use of natural proteins as drug delivery vehicles holds great promise due to various functionalities of proteins. in the current study, we exploited a natural protein, groel, which possesses a double layer cage structure, as a hydrophobic drug container, which is switchable by atp binding to a hydrophilic status, to design a novel and intelligent hydrophobic drug delivery molecular machine with a controlled drug release profile. when loaded with the hydrophobic antitumor drug, doxorubicin (dox), groel was able to shield the drug from the aqueous phase of blood, releasing the drug once in the presence of a critical concentration of atp at the tumor site. unexpectedly, we found that groel has a specific affinity for the cell structural protein, plectin, which is expressed at abnormally elevated levels on the membranes of tumor cells but not in normal cells. this finding, in combination with the atp sensitivity, makes groel a superior natural tumor targeting nanocarrier. our data show that groel-dox is able to effectively, and highly selectively, deliver the hydrophobic drug to fast growing tumors without overt adverse effects on the major organs. groel is therefore a promising drug delivery platform that can overcome the obstacles to hydrophobic drug targeting and delivery. |
| WOS关键词 | DODECYL-SULFATE ; PROTEIN ; CANCER ; NANOPARTICLES ; ATP ; STRATEGIES ; MECHANISM ; DISTANCE ; RELEASE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000425559700038 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177975 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Gao, Ning; Nie, Guangjun |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beiyitiao 11, Beijing 100190, Peoples R China 2.Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China 3.Tsinghua Univ, Beijing Innovat Ctr Struct Biol, Sch Life Sci, Beijing 100084, Peoples R China 4.Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Jilin, Peoples R China 5.Peking Univ, Sch Life Sci, Peking Tsinghua Joint Ctr Life Sci, State Key Lab Membrane Biol, Beijing 100871, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yi,Du, Chong,Sun, Cuiji,et al. Chaperonin-groel as a smart hydrophobic drug delivery and tumor targeting molecular machine for tumor therapy[J]. Nano letters,2018,18(2):921-928. |
| APA | Yuan, Yi.,Du, Chong.,Sun, Cuiji.,Zhu, Jin.,Wu, Shan.,...&Nie, Guangjun.(2018).Chaperonin-groel as a smart hydrophobic drug delivery and tumor targeting molecular machine for tumor therapy.Nano letters,18(2),921-928. |
| MLA | Yuan, Yi,et al."Chaperonin-groel as a smart hydrophobic drug delivery and tumor targeting molecular machine for tumor therapy".Nano letters 18.2(2018):921-928. |
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