T-1-mediated nanosensor for immunoassay based on an activatable mno2 nanoassembly
文献类型：期刊论文
| 作者 | Liu, Zixin1,2,3; Xianyu, Yunlei2,3; Zheng, Wenshu2,3; Zhang, Jiangjiang2,3; Luo, Yunjing1; Chen, Yiping2,3; Dong, Mingling2,3; Wu, Jing2,3; Jiang, Xingyu2,3,4 |
| 刊名 | Analytical chemistry
 |
| 出版日期 | 2018-02-20 |
| 卷号 | 90期号:4页码:2765-2771 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.7b04817 |
| 通讯作者 | Luo, yunjing(luoyj@bjut.edu.cn) ; Chen, yiping(chenyp@nanoctr.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Current magnetic relaxation switching (mrs) sensors for detection of trace targets in complex samples still suffer from limitations in terms of relatively low sensitivity and poor stability. to meet this challenge, we develop a longitudinal relaxation time (t-1)-based nano sensor by using mn2+ released from the reduction of a mno, nanoassembly that can induce the change of t-1, and thus can greatly improve the sensitivity and overcome the "hook effect" of conventional mrs. through the specific interaction between antigen and the antibodyfunctionalized mno, nanoassembly, the t-1 signal of mn2+ released from the nanoassembly is quantitatively determined by the antigen, which allows for highly sensitive and straightforward detection of targets. this approach broadens the applicability of magnetic biosensors and has great potential for applications in early diagnosis of disease biomarkers. |
| WOS关键词 | MAGNETIC-RELAXATION SWITCH ; SIGNAL AMPLIFICATION ; COMBINATION THERAPY ; CLICK CHEMISTRY ; ONE-STEP ; NANOPARTICLES ; RESONANCE ; NANOMATERIALS ; PEROXIDASE ; MECHANISM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000426143100052 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2177986 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Luo, Yunjing; Chen, Yiping; Jiang, Xingyu |
| 作者单位 | 1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 PingLeYuan, Beijing 100124, Peoples R China 2.Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, 11 BeiYiTiao, Beijing 100190, Peoples R China 3.Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, 11 BeiYiTiao, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, 19 A YuQuan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zixin,Xianyu, Yunlei,Zheng, Wenshu,et al. T-1-mediated nanosensor for immunoassay based on an activatable mno2 nanoassembly[J]. Analytical chemistry,2018,90(4):2765-2771. |
| APA | Liu, Zixin.,Xianyu, Yunlei.,Zheng, Wenshu.,Zhang, Jiangjiang.,Luo, Yunjing.,...&Jiang, Xingyu.(2018).T-1-mediated nanosensor for immunoassay based on an activatable mno2 nanoassembly.Analytical chemistry,90(4),2765-2771. |
| MLA | Liu, Zixin,et al."T-1-mediated nanosensor for immunoassay based on an activatable mno2 nanoassembly".Analytical chemistry 90.4(2018):2765-2771. |
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来源：高能物理研究所
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