Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity
文献类型：期刊论文
| 作者 | Cai, Chengxu1,2; Wang, Mingzhe1,2; Wang, Xinyi1; Wang, Bing3; Chen, Hanqing3; Chen, Jian3; Chen, Chunying1; Feng, Weiyue3 |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 18期号:8页码:5306-5313 |
| 关键词 | Gold nanoparticle Transferrin Pegylation Adsorption Target delivery |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2018.15435 |
| 通讯作者 | Chen, chunying() ; Feng, weiyue() |
| 英文摘要 | Polyethylene glycol (peg) has been frequently used for surface modification of nanoparticles (nps) to reduce non-specific binding of proteins on nps. the investigation of protein absorption on pegylated nanoparticles is necessary. in the work, the conjugation of transferrin (tf) to pegylated aunps via adsorption or bonding was studied. the 13 nm aunps were coated with various molecular weight (300, 2000, 5000) carboxyl and methoxy peg thiol. the presence of tf on pegylated aunp was characterized by dynamic light scattering (dls) and infrared spectroscopy (ir). the data of ir confirmed the presence of tf on pegylated aunps. the diameter decrease of pegylated aunps after tf adsorption was observed by dls measurement, which is attributed to competitive adsorption between tf and peg molecules. these phenomena may be important to the preservation of tf targeting specificity on pegylated aunps. |
| WOS关键词 | PROTEIN CORONA ; POLYETHYLENE-GLYCOL ; SURFACE ; RECEPTOR ; NANOCARRIERS ; ANTIBODIES ; ADSORPTION ; IMPACT ; CELLS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000426059800015 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178001 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying; Feng, Weiyue |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Chengxu,Wang, Mingzhe,Wang, Xinyi,et al. Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity[J]. Journal of nanoscience and nanotechnology,2018,18(8):5306-5313. |
| APA | Cai, Chengxu.,Wang, Mingzhe.,Wang, Xinyi.,Wang, Bing.,Chen, Hanqing.,...&Feng, Weiyue.(2018).Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity.Journal of nanoscience and nanotechnology,18(8),5306-5313. |
| MLA | Cai, Chengxu,et al."Transferrin adsorbed on pegylated gold nanoparticles and its relevance to targeting specificity".Journal of nanoscience and nanotechnology 18.8(2018):5306-5313. |
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