D-alanyl-d-alanine-modified gold nanoparticles form a broad-spectrum sensor for bacteria
文献类型：期刊论文
| 作者 | Yang, Xinglong1,2,3,5; Dang, Yan4; Lou, Jinli4; Shao, Huawu2; Jiang, Xingyu1,3 |
| 刊名 | Theranostics
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:5页码:1449-1457 |
| 关键词 | Gold nanoparticles D-amino acid Bacteria Spontaneous bacterial peritonitis Colorimetric biosensor |
| ISSN号 | 1838-7640 |
| DOI | 10.7150/thno.22540 |
| 通讯作者 | Shao, huawu(shaohw@cib.ac.cn) ; Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Rationale: rapid and facile detection of pathogenic bacteria is challenging due to the requirement of large-scale instruments and equipment in conventional methods. we utilize d-amino acid as molecules to selectively target bacteria because bacteria can incorporate dada in its cell wall while mammalian cells or fungi cannot. methods: we show a broad-spectrum bacterial detection system based on d-amino acid-capped gold nanoparticles (aunps). aunps serve as the signal output that we can monitor without relying on any complex instruments. results: in the presence of bacteria, the aunps aggregate and the color of aunps changes from red to blue. this convenient color change can distinguish between staphylococcus aureus (s. aureus) and methicillin-resistant staphylococcus aureus (mrsa). this system can be applied for detection of ascites samples from patients. conclusion: these d-amino acid-modified aunps serve as a promising platform for rapid visual identification of pathogens in the clinic. |
| WOS关键词 | D-AMINO ACIDS ; MULTIDRUG-RESISTANT BACTERIA ; CELL-WALL ; PEPTIDOGLYCAN BIOSYNTHESIS ; SILVER NANOPARTICLES ; PHOTOTHERMAL THERAPY ; MEDIATED GROWTH ; SMALL MOLECULES ; NAKED EYE ; CANCER |
| WOS研究方向 | Research & Experimental Medicine |
| WOS类目 | Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000424515900020 |
| 出版者 | IVYSPRING INT PUBL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178044 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Shao, Huawu; Jiang, Xingyu |
| 作者单位 | 1.ZhongGuanCun BeiYiTiao, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Natl Ctr NanoSci & Technol,CAS Ctr Excellence Nan, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Capital Med Univ, Beijing Youan Hosp, Dept Clin Lab, 8 Youan Men Wai Xi TouTiao, Beijing 100069, Peoples R China 5.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xinglong,Dang, Yan,Lou, Jinli,et al. D-alanyl-d-alanine-modified gold nanoparticles form a broad-spectrum sensor for bacteria[J]. Theranostics,2018,8(5):1449-1457. |
| APA | Yang, Xinglong,Dang, Yan,Lou, Jinli,Shao, Huawu,&Jiang, Xingyu.(2018).D-alanyl-d-alanine-modified gold nanoparticles form a broad-spectrum sensor for bacteria.Theranostics,8(5),1449-1457. |
| MLA | Yang, Xinglong,et al."D-alanyl-d-alanine-modified gold nanoparticles form a broad-spectrum sensor for bacteria".Theranostics 8.5(2018):1449-1457. |
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来源：高能物理研究所
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