Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes
文献类型：期刊论文
| 作者 | Guo, Mengyu1,2,4; Zhou, Guoqiang3; Liu, Zhu3; Liu, Jing1,2; Tang, Jinglong1,2; Xiao, Yating4; Xu, Wenshi3; Liu, Ying1,2; Chen, Chunying1,2,4 |
| 刊名 | Science bulletin
 |
| 出版日期 | 2018-01-30 |
| 卷号 | 63期号:2页码:92-100 |
| ISSN号 | 2095-9273 |
| 关键词 | Core-shell nanofiber Melanoma Electrospinning Controlled drug release |
| DOI | 10.1016/j.scib.2017.11.018 |
| 通讯作者 | Liu, ying(liuy@nanoctr.cn) ; Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | Doxorubicin (dox) is widely used in cancer therapy. however, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. in our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. the core region consisted of poly (lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin. dox was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. this implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a dox-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. compared with the traditional intravenous administration, the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity. (c) 2017 science china press. published by elsevier b.v. and science china press. all rights reserved. |
| WOS关键词 | DRUG-DELIVERY ; NANOPARTICLES ; CHEMOTHERAPY ; THERAPY ; STRATEGIES ; CISPLATIN ; DIAGNOSIS ; EFFICIENT ; RESECTION ; TOXICITY |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000425945900005 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178061 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, Ying; Chen, Chunying |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Hebei Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Med Chem & Mol Diag, Baoding 050011, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Mengyu,Zhou, Guoqiang,Liu, Zhu,et al. Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes[J]. Science bulletin,2018,63(2):92-100. |
| APA | Guo, Mengyu.,Zhou, Guoqiang.,Liu, Zhu.,Liu, Jing.,Tang, Jinglong.,...&Chen, Chunying.(2018).Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes.Science bulletin,63(2),92-100. |
| MLA | Guo, Mengyu,et al."Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes".Science bulletin 63.2(2018):92-100. |
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来源：高能物理研究所
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