Bactericidal effects of silver nanoparticles on lactobacilli and the underlying mechanism
文献类型：期刊论文
| 作者 | Tian, Xin1; Jiang, Xiumei2,3; Welch, Cara2,3; Croley, Timothy R.2,3; Wong, Tit-Yee4; Chen, Chao5; Fan, Sanhong5; Chong, Yu1; Li, Ruibin1; Ge, Cuicui1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2018-03-14 |
| 卷号 | 10期号:10页码:8443-8450 |
| ISSN号 | 1944-8244 |
| 关键词 | Silver nanoparticle Antibacterial Lactobacilli Hydroxyl radical Acidic environment |
| DOI | 10.1021/acsami.7b17274 |
| 通讯作者 | Yin, jun-jie(junjie.yin@fda.hhs.gov) |
| 英文摘要 | While the antibacterial properties of silver nanoparticles (agnps) have been demonstrated across a spectrum of bacterial pathogens, the effects of agnps on the beneficial bacteria are less clear. to address this issue, we compared the antibacterial activity of agnps against two beneficial lactobacilli (lactobacillus delbrueckii subsp. bulgaricus and lactobacillus casei) and two common opportunistic pathogens (escherichia coli and staphylococcus aureus). our results demonstrate that those lactobacilli are highly susceptible to agnps, while the opportunistic pathogens are not. acidic environment caused by the lactobacilli is associated with the bactericidal effects of agnps. our mechanistic study suggests that the acidic growth environment of lactobacilli promotes agnp dissolution and hydroxyl radical (center dot oh) overproduction. furthermore, increases in silver ions (ag+) and center dot oh deplete the glutathione pool inside the cell, which is associated with the increase in cellular reactive oxygen species (ros). high levels of ros may further induce dna damage and lead to cell death. when e. coli and s. aureus are placed in a similar acidic environment, they also become more susceptible to agnps. this study provides a mechanistic description of a ph-ag+-center dot oh bactericidal pathway and will contribute to the responsible development of products containing agnps. |
| WOS关键词 | ANTIBACTERIAL ACTIVITY ; OXIDATIVE STRESS ; FOOD CONTAINERS ; GUT MICROBIOTA ; GRAPHENE OXIDE ; NANOSILVER ; GLUTATHIONE ; GENERATION ; TOXICITY ; RADICALS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000427910800008 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178063 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yin, Jun-Jie |
| 作者单位 | 1.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China 2.US FDA, Ctr Food Safety & Appl Nutr, Off Regulatory Sci, Div Analyt Chem, College Pk, MD 20740 USA 3.US FDA, Ctr Food Safety & Appl Nutr, Off Dietary Supplement Programs, College Pk, MD 20740 USA 4.Univ Memphis, Dept Biol Sci, Memphis, TN 38120 USA 5.Shanxi Univ, Sch Life Sci, Taiyuan 030006, Shanxi, Peoples R China 6.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Inst High Energy Phys, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Xin,Jiang, Xiumei,Welch, Cara,et al. Bactericidal effects of silver nanoparticles on lactobacilli and the underlying mechanism[J]. Acs applied materials & interfaces,2018,10(10):8443-8450. |
| APA | Tian, Xin.,Jiang, Xiumei.,Welch, Cara.,Croley, Timothy R..,Wong, Tit-Yee.,...&Yin, Jun-Jie.(2018).Bactericidal effects of silver nanoparticles on lactobacilli and the underlying mechanism.Acs applied materials & interfaces,10(10),8443-8450. |
| MLA | Tian, Xin,et al."Bactericidal effects of silver nanoparticles on lactobacilli and the underlying mechanism".Acs applied materials & interfaces 10.10(2018):8443-8450. |
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