Imparting designer biorecognition functionality to metal-organic frameworks by a dna-mediated surface engineering strategy
文献类型：期刊论文
| 作者 | Ning, Weiyu1; Di, Zhenghan1; Yu, Yingjie2; Zeng, Pingmei3; Di, Chunzhi1; Chen, Daquan4; Kong, Xueqian3; Nie, Guangjun1; Zhao, Yuliang1; Li, Lele1 |
| 刊名 | Small
 |
| 出版日期 | 2018-03-15 |
| 卷号 | 14期号:11页码:8 |
| ISSN号 | 1613-6810 |
| 关键词 | Biorecognition Dna Metal-organic frameworks Surface engineering |
| DOI | 10.1002/smll.201703812 |
| 通讯作者 | Zhao, yuliang(zhaoyl@nanoctr.cn) ; Li, lele(lilele@nanoctr.cn) |
| 英文摘要 | Surface functionality is an essential component for processing and application of metal-organic frameworks (mofs). a simple and cost-effective strategy for dna-mediated surface engineering of zirconium-based nanoscale mofs (nmofs) is presented, capable of endowing them with specific molecular recognition properties and thus expanding their potential for applications in nanotechnology and biotechnology. it is shown that efficient immobilization of functional dna on nmofs can be achieved via surface coordination chemistry. with this strategy, it is demonstrated that such porphyrin-based nmofs can be modified with a dna aptamer for targeting specific cancer cells. furthermore, the dna-nmofs can facilitate the delivery of therapeutic dna (e.g., cpg) into cells for efficient recognition of endosomal toll-like receptor 9 and subsequent enhanced immunostimulatory activity in vitro and in vivo. no apparent toxicity is observed with systemic delivery of the dna-nmofs in vivo. overall, these results suggest that the strategy allows for surface functionalization of mofs with different functional dnas, extending the use of these materials to diverse applications in biosensor, bioimaging, and nanomedicine. |
| WOS关键词 | ASSISTED LIGAND INCORPORATION ; PHOTODYNAMIC THERAPY ; ANTITUMOR IMMUNITY ; LINKER EXCHANGE ; DRUG-DELIVERY ; CHECKPOINT BLOCKADE ; BREAST-CANCER ; NANOPARTICLES ; PLATFORM ; MOLECULES |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000427592400016 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178079 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Yuliang; Li, Lele |
| 作者单位 | 1.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.SUNY Stony Brook, Dept Mat Sci & Engn, Stony Brook, NY 11794 USA 3.Zhejiang Univ, Dept Chem, Ctr Chem High Performance & Novel Mat, Hangzhou 310027, Peoples R China 4.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ning, Weiyu,Di, Zhenghan,Yu, Yingjie,et al. Imparting designer biorecognition functionality to metal-organic frameworks by a dna-mediated surface engineering strategy[J]. Small,2018,14(11):8. |
| APA | Ning, Weiyu.,Di, Zhenghan.,Yu, Yingjie.,Zeng, Pingmei.,Di, Chunzhi.,...&Li, Lele.(2018).Imparting designer biorecognition functionality to metal-organic frameworks by a dna-mediated surface engineering strategy.Small,14(11),8. |
| MLA | Ning, Weiyu,et al."Imparting designer biorecognition functionality to metal-organic frameworks by a dna-mediated surface engineering strategy".Small 14.11(2018):8. |
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来源：高能物理研究所
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